Preoperative risk assessment is important yet inexact in older patients because physiologic
reserves are difficult to measure. Frailty is thought to estimate physiologic reserves,
although its use has not been evaluated in surgical patients. We designed a study
to determine if frailty predicts surgical complications and enhances current perioperative
risk models.
We prospectively measured frailty in 594 patients (age 65 years or older) presenting
to a university hospital for elective surgery between July 2005 and July 2006. Frailty
was classified using a validated scale (0 to 5) that included weakness, weight loss,
exhaustion, low physical activity, and slowed walking speed. Patients scoring 4 to
5 were classified as frail, 2 to 3 were intermediately frail, and 0 to 1 were nonfrail.
Main outcomes measures were 30-day surgical complications, length of stay, and discharge
disposition. Multiple logistic regression (complications and discharge) and negative
binomial regression (length of stay) were done to analyze frailty and postoperative
outcomes associations.
Preoperative frailty was associated with an increased risk for postoperative complications
(intermediately frail: odds ratio [OR] 2.06; 95% CI 1.18-3.60; frail: OR 2.54; 95%
CI 1.12-5.77), length of stay (intermediately frail: incidence rate ratio 1.49; 95%
CI 1.24-1.80; frail: incidence rate ratio 1.69; 95% CI 1.28-2.23), and discharge to
a skilled or assisted-living facility after previously living at home (intermediately
frail: OR 3.16; 95% CI 1.0-9.99; frail: OR 20.48; 95% CI 5.54-75.68). Frailty improved
predictive power (p < 0.01) of each risk index (ie, American Society of Anesthesiologists,
Lee, and Eagle scores).
Frailty independently predicts postoperative complications, length of stay, and discharge
to a skilled or assisted-living facility in older surgical patients and enhances conventional
risk models. Assessing frailty using a standardized definition can help patients and
physicians make more informed decisions.
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