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      Budesonide-loaded solid lipid nanoparticles for pulmonary delivery: preparation, optimization, and aerodynamic behavior.

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          Abstract

          Advantages of lipid nanoparticles for pulmonary applications are possibility of deep lung deposition with prolonged release and low toxicity. This study aimed to evaluate the effects of formulation and processing parameters on particle size of prepared SLNs. Budesonide-loaded solid lipid nanoparticles (BUD-SLNs) were prepared with different values of drug content, ultrasonication amplitude, and homogenization time and the data were modeled using artificial neural networks (ANNs). Optimal conditions for fabrication of small-sized particles of 170-200 nm were found to be low drug content with high-amplitude and high-homogenization time. In vitro aerosolization performance of BUD-SLNs was then compared to that of commercial budesonide which indicated enhancement in fine particle fraction value.

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          Author and article information

          Journal
          Artif Cells Nanomed Biotechnol
          Artificial cells, nanomedicine, and biotechnology
          Informa UK Limited
          2169-141X
          2169-1401
          Dec 2016
          : 44
          : 8
          Affiliations
          [1 ] a Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences , Tehran , Iran.
          [2 ] b Department of Biochemistry, Faculty of Medicine, Hamedan University of Medical Sciences , Hamedan , Iran.
          [3 ] c Medical Biomaterials Research Center, Tehran University of Medical Sciences , Tehran , Iran.
          Article
          10.3109/21691401.2015.1129614
          26758698

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