Distribution of Stanniocalcin 1 in Rat Kidney and Its Regulation by Vitamin D ₃

Abstract

Stanniocalcin is a glycoprotein hormone first described in fish as a hypocalcemic factor, and recently its mammalian counterpart has been identified. Localization of stanniocalcin 1 and its regulation of expression were determined in control and 1α,25-dihydroxyvitamin D₃-treated rats. Immunoreactivity for stanniocalcin 1 was detected in the loop of Henle, macula densa cells, distal convoluted tubule (DCT), and cortical collecting duct (CCD), and also faintly in the medullary collecting ducts. Pre-embedding electron-microscopic immunocytochemistry revealed stanniocalcin 1 in the apical membrane of cells of loop of Henle, DCT, and principal cells of CCD. The expression of stanniocalcin 1 was increased by elevated plasma calcium via 1α,25-dihydroxyvitamin D₃ treatment. In conclusion, stanniocalcin 1 was expressed in the apical membrane of distal nephron segments and enhanced by vitamin D₃.

Journal

Journal ID (publisher-id): EXN

Journal ID (nlm-ta): Nephron Exp Nephrol

Journal ID (doi): 10.1159/issn.1660-2129

Title: Cardiorenal Medicine

Publisher: S. Karger AG

ISSN (Electronic): 1660-2129

Publication date Subscription-year: 2001

Publication date (Print): 2001

Publication date (Electronic): 07 November 2001

Volume: 9

Issue: 6

Pages: 428-435

Affiliations

^aDivision of Nephrology and Endocrinology, University of Tokyo, and ^bDepartment of Biological Sciences, Tokyo Institute of Technology, Yokohama, Japan

Article

Publisher ID: 52642 Other ID: Exp Nephrol 2001;9:428–435

DOI: 10.1159/000052642

PubMed ID: 11702003

Copyright statement: © 2001 S. Karger AG, Basel

License:

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Page count

Figures: 5, Tables: 1, References: 39, Pages: 8

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Categories

Subject: Original Paper