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      Acute Interstitial Nephritis A Distinct Clinico-Pathological Entity?

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          Abstract

          The term acute interstitial nephritis (AIN) has generally been used to describe the pathologic changes observed in the kidney after a variety of ‘insults’, but many authorities have questioned whether AIN constitutes a distinct clinico-pathological entity. This report describes 5 patients in whom the diagnosis of AIN was established after ruling out other processes which could have produced similar clinical or pathologic findings. All patients presented with severe renal failure but improved both clinically and biochemically within several months. Two patients improved spontaneously and 3 improved in association with the institution of corticosteroid therapy. No etiologic agent was readily apparent in any of the patients.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1972
          1972
          27 November 2008
          : 9
          : 1
          : 10-26
          Affiliations
          Department of Medicine and Pathology and the Division of Renal Diseases, Rhode Island Hospital, and Division of Biological and Medical Sciences, Brown University, Providence, R. I.
          Article
          180130 Nephron 1972;9:10–26
          10.1159/000180130
          4557691
          © 1972 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 17
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