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      Neural control of blood pressure in women: differences according to age

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          Abstract

          Purpose

          The blood pressure “error signal” represents the difference between an individual’s mean diastolic blood pressure and the diastolic blood pressure at which 50% of cardiac cycles are associated with a muscle sympathetic nerve activity burst (the “T50”). In this study we evaluated whether T50 and the error signal related to the extent of change in blood pressure during autonomic blockade in young and older women, to study potential differences in sympathetic neural mechanisms regulating blood pressure before and after menopause.

          Methods

          We measured muscle sympathetic nerve activity and blood pressure in 12 premenopausal (25±1 years) and 12 postmenopausal women (61±2 years) before and during complete autonomic blockade with trimethaphan camsylate.

          Results

          At baseline, young women had a negative error signal (−8±1 versus 2±1 mmHg, p<0.001; respectively) and lower muscle sympathetic nerve activity (15±1 versus 33±3 bursts/min, p<0.001; respectively) than older women. The change in diastolic blood pressure after autonomic blockade was associated with baseline T50 in older women (r=−0.725, p=0.008) but not in young women (r=−0.337, p=0.29). Women with the most negative error signal had the lowest muscle sympathetic nerve activity in both groups (young: r=0.886, p<0.001; older: r=0.870, p<0.001).

          Conclusions

          Our results suggest that there are differences in baroreflex control of muscle sympathetic nerve activity between young and older women, using the T50 and error signal analysis. This approach provides further information on autonomic control of blood pressure in women.

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          Author and article information

          Journal
          9106549
          2198
          Clin Auton Res
          Clin. Auton. Res.
          Clinical autonomic research : official journal of the Clinical Autonomic Research Society
          0959-9851
          1619-1560
          9 September 2017
          16 February 2017
          June 2017
          01 June 2018
          : 27
          : 3
          : 157-165
          Affiliations
          [1 ]LFE Research Group, Department of Health and Human Performance, Technical University of Madrid, Madrid, Spain
          [2 ]Department of Anesthesiology, Mayo Clinic, Rochester, MN, USA
          [3 ]School of Physiology and Pharmacology, University of Bristol, Bristol, United Kingdom
          [4 ]Thermal and Mountain Medicine Division, U.S. Army Research Institute of Environmental Medicine, Natick, MA, USA
          [5 ]Institute of Neuroscience and Physiology, The Sahlgren Academy at Gothenburg University, Goteborg, Sweden
          [6 ]Department of Kinesiology, University of Wisconsin-Madison, Madison, WI, USA
          Author notes
          Corresponding author: Ana B. Peinado, Ph.D., Department of Health and Human Performance, Technical University of Madrid, Martín Fierro, 7. Madrid, 28040. Spain, Phone: +34 913364070, Fax: +34 913364126, anabelen.peinado@ 123456upm.es
          Article
          PMC5604236 PMC5604236 5604236 nihpa904846
          10.1007/s10286-017-0403-0
          5604236
          28205011
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          Article

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