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      Call for Papers: Green Renal Replacement Therapy: Caring for the Environment

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      Osteopontin and Calcium Stone Formation

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          Abstract

          Osteopontin (OPN) is a phosphorylated protein of wide tissue distribution that is found in association with dystrophic calcification including in the organic matrix of kidney stones. It is a strong inhibitor of crystal formation and growth in vitro, but there is still debate regarding its effects upon crystal adhesion to tubular epithelial cells. In this brief review, we will outline the evidence implicating OPN in stone disease with the primary emphasis being on the interaction of OPN with calcium oxalate (CaOx), the major constituent of calcium containing stones. Finally, preliminary data is presented regarding the amounts and features of OPN present in the urine of stone formers and normal individuals.

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          Osteopontin as a means to cope with environmental insults: regulation of inflammation, tissue remodeling, and cell survival.

          D T Denhardt, M Noda, A W O'Regan … (2001)
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            Flexible structures of SIBLING proteins, bone sialoprotein, and osteopontin.

            Jane M Young, D Torchia, B Fohr … (2001)
            Bone sialoprotein (BSP) and osteopontin (OPN) are two members of the SIBLING (Small Integrin-Binding LIgand, N-linked Glycoprotein) family of genetically related proteins that are clustered on human chromosome 4. We present evidence that this entire family is the result of duplication and subsequent divergent evolution of a single ancient gene. The solution structures of these two post-translationally modified recombinant proteins were solved by one dimensional proton NMR and transverse relaxation times. The polypeptide backbones of both free BSP and OPN rapidly sample an ensemble of conformations consistent with them both being completely unstructured in solution. This flexibility appears to enable these relatively small glycoproteins to rapidly associate with a number of different binding partners including other proteins as well as the mineral phase of bones and teeth. These proteins often function by bridging two proteins of fixed structures into a biologically active complex. Copyright 2001 Academic Press.
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              Osteopontin--a molecule for all seasons

              M Mazzali (2002)
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                Author and article information

                Journal
                Journal ID (publisher-id): NEP
                Journal ID (nlm-ta): Nephron Physiol
                Journal ID (doi): 10.1159/issn.1660-2137
                Title: Nephron Physiology
                Publisher: S. Karger AG
                ISBN: 978-3-8055-7852-3
                ISBN: 978-3-318-06156-7
                ISSN (Electronic): 1660-2137
                Publication date Subscription-year: 2004
                Publication date (Print): October 2004
                Publication date (Electronic): 19 October 2004
                Volume: 98
                Issue: 2
                Pages: p43-p47
                Affiliations
                aNephrology Division, Veterans Affairs Medical Center, and Medical College of Wisconsin, Milwaukee, Wisc., USA; bPhagocyte Laboratory, MRC Center for Inflammation Research, University of Edinburgh Medical School, Edinburgh, UK
                Article
                Publisher ID: 80263 Other ID: Nephron Physiol 2004;98:p43–p47
                DOI: 10.1159/000080263
                PubMed ID: 15499214
                SO-VID: 04f93a51-7f2a-4045-bd37-54ff44b418c0
                Copyright © © 2004 S. Karger AG, Basel
                License:

                Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

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                Page count
                Figures: 2, References: 46, Pages: 1
                Categories
                Subject: Paper

                ScienceOpen disciplines: Cardiovascular Medicine,Nephrology
                Keywords: Nephrolithiasis,Crystal formation,Calcium oxalate,Kidney calculi,Osteopontin
                Data availability:
                ScienceOpen disciplines: Cardiovascular Medicine, Nephrology
                Keywords: Nephrolithiasis, Crystal formation, Calcium oxalate, Kidney calculi, Osteopontin

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