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      DnaK, DnaJ, and GrpE are required for flagellum synthesis in Escherichia coli.

      Journal of Bacteriology

      biosynthesis, Transcription, Genetic, genetics, Escherichia coli, Cell Movement, metabolism, ultrastructure, Escherichia coli Proteins, Flagella, physiology, Flagellin, Genes, Regulator, HSP40 Heat-Shock Proteins, HSP70 Heat-Shock Proteins, Heat-Shock Proteins, Mutation, Recombinant Fusion Proteins, Bacterial Proteins

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          Abstract

          The DnaK, DnaJ, and GrpE heat shock proteins are required for motility of Escherichia coli. Cells deleted for dnaK or dnaJ, or with some mutations in the dnaK or grpE gene, are nonmotile, lack flagella, exhibit a 10- to 20-fold decrease in the rate of synthesis of flagellin, and show reduced rates of transcription of both the flhD master operon (encoding FlhD and FlhC) and the fliA operon (encoding sigma F). Genetic studies suggest that DnaK and DnaJ define a regulatory pathway affecting flhD and fliA synthesis that is independent of cyclic AMP-catabolite gene activator protein or the chemotaxis system.

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          207695
          1400176

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