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      Is there a role for leptin in the reduction of depression symptoms during weight loss therapy in obese adolescent girls and boys?

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          Abstract

          Several studies have sought to clarify the association between adolescent obesity and psychological distress. Recently, a biological link between leptin resistance and depression has been proposed. The aim of the present study was to examine changes in leptin concentrations as a potential predictor of reduced depression symptoms in obese adolescents during long-term interdisciplinary weight loss therapy. Seventy-five obese adolescents (age: 16.28±2.37 years; BMI: 35.65±4.64 kg/m2) engaged in a long-term interdisciplinary therapy for weight loss. They were evaluated at baseline and after 1 year of treatment for body composition, serum analyses and depression symptomatology. After therapy, body mass BMI, fat mass (% and kg), waist circumference, visceral, subcutaneous and visceral/subcutaneous fat and depression symptoms decreased and lean mass (%) increased significantly. There was an improvement in inflammatory profiles with a significant reduction in leptin and increase in adiponectin. Regression analyses showed that decreased leptin predicted amelioration in depression symptoms independent of age, gender and changes in visceral fat, body mass, fat mass (%) and leptin/adiponectin ratio. These associations appear stronger in girls than boys. The attenuation of hyperleptinemia appears to play an important role in the association between weight loss and depression, particularly in obese girls.

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          Affiliations
          [1 ] Post-Graduate Program of Interdisciplinary Health Sciences, Universidade Federal de São Paulo, Santos, SP, Brazil. Electronic address: carvalhoferreira.jp@gmail.com.
          [2 ] Post-Graduate Program of Nutrition - Universidade Federal de São Paulo, São Paulo, SP, Brazil.
          [3 ] Weight Science, São Paulo, SP, Brazil.
          [4 ] Department of Psychobiology, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
          [5 ] Institute of Psychological Sciences, University of Leeds, Leeds, West Yorkshire, United Kingdom.
          [6 ] Post-Graduate Program of Interdisciplinary Health Sciences, Universidade Federal de São Paulo, Santos, SP, Brazil; Post-Graduate Program of Nutrition - Universidade Federal de São Paulo, São Paulo, SP, Brazil. Electronic address: ana.damaso@unifesp.br.
          Journal
          Peptides
          Peptides
          1873-5169
          0196-9781
          Mar 2015
          : 65
          25629253 S0196-9781(15)00007-8 10.1016/j.peptides.2014.11.010
          Copyright © 2015 Elsevier Inc. All rights reserved.

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