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      Prevalence of Erectile Dysfunction and Associated Factors among Hypertensive Patients Attending Governmental Health Institutions in Gondar City, Northwest Ethiopia: A Cross-Sectional Study

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          Abstract

          Introduction

          Erectile dysfunction is a common sexual problem affecting men with hypertension. It may result in withdrawal from sexual engagement, decreased work productivity, psychosocial problems including poor self-esteem and depression, and reduction in quality of life for both the affected men and their female partners.

          Objective

          This study was aimed to determine the prevalence of erectile dysfunction and associated factors among hypertensive patients attending governmental health institutions in Gondar city, Northwest Ethiopia.

          Materials and Methods

          An institutional-based cross-sectional study was conducted on 423 hypertensive men randomly selected using a systematic random sampling technique. Erectile dysfunction was assessed using the International Index of Erectile Function-5 tool. Sociodemographic, clinical, and behavioral factors were also collected using pretested interviewer-administered questionnaires. Data were entered into EpiData version 4.6 and analyzed using Stata-14. Binary logistic regression was performed to identify factors associated with erectile dysfunction. The level of significance was computed at a p value ≤ 0.05.

          Results

          The mean age of the study participants was 58.84 ± 13.52 years. The prevalence of erectile dysfunction among hypertensive men was 46.34% (95% CI: 41.61, 51.12). About 28% of them had a mild form of erectile dysfunction while nearly 6% had severe forms. Age above 60 years (AOR = 3.8, 95% CI: 1.62, 6.55), stage II hypertension (AOR = 3.5, 95% CI: 1.63, 5.74), hypertension duration >10 years (AOR = 2.5, 95% CI:1.12, 4.19), comorbidity (AOR = 1.7, 95% CI: 1.04, 3.15), depression (AOR = 2.35, 95% CI: 1.31, 4.21), and being physically active (AOR = 0.48, 95% CI: 0.28, 0.83) were factors significantly associated with erectile dysfunction.

          Conclusion

          Nearly half of the study participants had some form of erectile dysfunction, indicating the presence of a high burden of the problem. Assessment of hypertensive men for erectile dysfunction should be part of routine medical care.

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          Most cited references51

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          2014 evidence-based guideline for the management of high blood pressure in adults: report from the panel members appointed to the Eighth Joint National Committee (JNC 8).

          Hypertension is the most common condition seen in primary care and leads to myocardial infarction, stroke, renal failure, and death if not detected early and treated appropriately. Patients want to be assured that blood pressure (BP) treatment will reduce their disease burden, while clinicians want guidance on hypertension management using the best scientific evidence. This report takes a rigorous, evidence-based approach to recommend treatment thresholds, goals, and medications in the management of hypertension in adults. Evidence was drawn from randomized controlled trials, which represent the gold standard for determining efficacy and effectiveness. Evidence quality and recommendations were graded based on their effect on important outcomes. There is strong evidence to support treating hypertensive persons aged 60 years or older to a BP goal of less than 150/90 mm Hg and hypertensive persons 30 through 59 years of age to a diastolic goal of less than 90 mm Hg; however, there is insufficient evidence in hypertensive persons younger than 60 years for a systolic goal, or in those younger than 30 years for a diastolic goal, so the panel recommends a BP of less than 140/90 mm Hg for those groups based on expert opinion. The same thresholds and goals are recommended for hypertensive adults with diabetes or nondiabetic chronic kidney disease (CKD) as for the general hypertensive population younger than 60 years. There is moderate evidence to support initiating drug treatment with an angiotensin-converting enzyme inhibitor, angiotensin receptor blocker, calcium channel blocker, or thiazide-type diuretic in the nonblack hypertensive population, including those with diabetes. In the black hypertensive population, including those with diabetes, a calcium channel blocker or thiazide-type diuretic is recommended as initial therapy. There is moderate evidence to support initial or add-on antihypertensive therapy with an angiotensin-converting enzyme inhibitor or angiotensin receptor blocker in persons with CKD to improve kidney outcomes. Although this guideline provides evidence-based recommendations for the management of high BP and should meet the clinical needs of most patients, these recommendations are not a substitute for clinical judgment, and decisions about care must carefully consider and incorporate the clinical characteristics and circumstances of each individual patient.
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            Tobacco Product Use Among Adults — United States, 2019

            Cigarette smoking remains the leading cause of preventable disease and death in the United States ( 1 ). The prevalence of current cigarette smoking among U.S. adults has declined over the past several decades, with a prevalence of 13.7% in 2018 ( 2 ). However, a variety of combustible, noncombustible, and electronic tobacco products are available in the United States ( 1 , 3 ). To assess recent national estimates of tobacco product use among U.S. adults aged ≥18 years, CDC analyzed data from the 2019 National Health Interview Survey (NHIS). In 2019, an estimated 50.6 million U.S. adults (20.8%) reported currently using any tobacco product, including cigarettes (14.0%), e-cigarettes (4.5%), cigars (3.6%), smokeless tobacco (2.4%), and pipes* (1.0%). † Most current tobacco product users (80.5%) reported using combustible products (cigarettes, cigars, or pipes), and 18.6% reported using two or more tobacco products. § The prevalence of any current tobacco product use was higher among males; adults aged ≤65 years; non-Hispanic American Indian/Alaska Native (AI/AN) adults; those whose highest level of educational attainment was a General Educational Development (GED) certificate; those with an annual household income 30% or unweighted denominator 30% or unweighted denominator <50. The figure is a bar chart showing the cigarette smoking status (current, former, or never) among current adult e-cigarette users, by age group. The prevalence of any current tobacco product use was higher among males (26.2%) than among females (15.7%) and among those aged 25–44 years (25.3%), 45–64 years (23.0%), or 18–24 years (18.2%) than among those aged ≥65 years (11.4%) (Table). Current tobacco product use was also higher among non-Hispanic AI/AN adults (29.3%), non-Hispanic adults of other †††† races (28.1%), non-Hispanic White adults (23.3%), non-Hispanic Black adults (20.7%), and Hispanic or Latino adults (13.2%) than among non-Hispanic Asian adults (11.0%); and among those living in the Midwest (23.7%) or South (22.9%) than among those in the Northeast (18.5%) or West (16.4%). The prevalence of current tobacco product use was higher among those whose highest educational attainment was a GED (43.7%) than among those with other levels of education; among those who were divorced/separated/widowed (23.5%) or single/never married/not living with a partner (23.0%) than among those married/living with a partner (19.2%); among those who had annual household income of <$35,000 (27.0%) than among those with higher income; and among LGB adults (29.9%) than among those who were heterosexual/straight (20.5%). Prevalence was also higher among adults who were uninsured (30.2%), insured by Medicaid (30.0%), or had some other public insurance (25.6%) than among those with private insurance (18.0%) or Medicare only (11.4%); among those who had a disability (26.9%) compared with those without (20.1%); and among those who had GAD-7 scores indicating mild (30.4%), moderate (34.2%) or severe (45.3%) anxiety than among those indicating no or minimal (18.4%) anxiety. Discussion In 2019, approximately one in five U.S. adults (50.6 million) reported currently using any tobacco product. Cigarettes were the most commonly used tobacco product among adults, and combustible tobacco products (cigarettes, cigars, or pipes) were used by most (80.5%) adult tobacco product users. Most of the death and disease from tobacco use in the United States is primarily caused by cigarettes and other combustible products ( 1 ); therefore, continued efforts to reduce all forms of combustible tobacco smoking among U.S. adults are warranted. Moreover, approximately one in five current tobacco product users (18.6%) reported using two or more tobacco products, and differences in prevalence of tobacco use were also seen across population groups, with higher prevalence among those with a GED, American Indian/Alaska Natives, uninsured adults and adults with Medicaid, and LGB adults. Each of these groups has experienced social, economic, and environmental stressors that might contribute to higher tobacco use prevalence ( 6 ). Comprehensive strategies at the national, state, and local levels, including targeted interventions and tailored community engagement, can reduce tobacco-related disease and death and help to mitigate tobacco-related disparities ( 1 , 4 , 6 ). U.S. adults also reported using various noncigarette tobacco products, with e-cigarettes being the most commonly used noncigarette tobacco product (4.5%). E-cigarette use was highest among adults aged 18–24 years (9.3%), with over half (56.0%) of these young adults reporting that they had never smoked cigarettes. In addition, the tobacco product with the highest percentage of users aged 18–24 years (24.5%) was e-cigarettes. E-cigarettes contain nicotine, which is highly addictive, can prime the brain for addiction to other drugs, and can harm brain development, which continues until about age 25 years ( 3 ). Although e-cigarette use was lower among the older age groups, more than 40% of e-cigarette users in the 25–44, 45–64 and ≥65 years age groups reported being former smokers. Although some evidence suggests that the use of e-cigarettes containing nicotine and more frequent use of e-cigarettes are associated with increased smoking cessation, smokers need to completely stop smoking cigarettes and stop using any other tobacco product to achieve meaningful health benefits ( 6 , 7 ). The U.S. Surgeon General concluded that there is presently inadequate evidence to conclude that e-cigarettes, in general, increase smoking cessation, and further research is needed on the effects that e-cigarettes have on cessation ( 7 ). Therefore, continued efforts to reduce use of all tobacco products, combustible and noncombustible, are needed. The findings in this report are subject to at least four limitations. First, the 59.1% response rate might have resulted in nonresponse bias, although sample weighting is designed to account for this. Second, self-reported responses were not validated by biochemical testing for cotinine (a biomarker indicating nicotine exposure); however, there is high correlation between self-reported smoking and smokeless use and cotinine levels ( 8 , 9 ). Third, because NHIS is limited to the noninstitutionalized U.S. civilian population, these results might not be generalizable to institutionalized populations and persons in the military. Finally, this analysis does not provide comparisons of prevalence estimates with previous surveys because changes in weighting and design methodology for the 2019 NHIS have the potential to affect comparisons of weighted survey estimates over time. §§§§ The implementation of comprehensive, evidence-based, population-level interventions in coordination with regulation of tobacco products, can reduce tobacco-related disease, disparities, and death in the United States ( 1 , 4 ). These evidence-based, population-level strategies include implementation of tobacco price increases, comprehensive smoke-free policies, high-impact antitobacco media campaigns, and barrier-free cessation coverage ( 1 ). As part of a comprehensive approach, targeted interventions are also warranted to reach subpopulations with the highest prevalence of use, which might vary by tobacco product type. Summary What is already known about this topic? Cigarette smoking remains the leading cause of preventable disease and death in the United States; however, a variety of new combustible, noncombustible, and electronic tobacco products are available in the United States. What is added by this report? In 2019, approximately 20.8% of U.S. adults (50.6 million) currently used any tobacco product. Cigarettes were the most commonly used tobacco product among adults, and e-cigarettes were the most commonly used noncigarette tobacco product (4.5%). The highest prevalence of e-cigarette use was among smokers aged 18–24 years (9.3%), with over half (56.0%) of these young adults reporting that they had never smoked cigarettes. What are the implications for public health practice? The implementation of comprehensive, evidence-based, population-level interventions, combined with targeted strategies, in coordination with regulation of tobacco products, can reduce tobacco-related disease and death in the United States. As part of a comprehensive approach, targeted interventions are also warranted to reach subpopulations with the greatest use, which might vary by tobacco product type.
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              Global Physical Activity Questionnaire (GPAQ): Nine Country Reliability and Validity Study

              Instruments to assess physical activity are needed for (inter)national surveillance systems and comparison. Male and female adults were recruited from diverse sociocultural, educational and economic backgrounds in 9 countries (total n = 2657). GPAQ and the International Physical Activity Questionnaire (IPAQ) were administered on at least 2 occasions. Eight countries assessed criterion validity using an objective measure (pedometer or accelerometer) over 7 days. Reliability coefficients were of moderate to substantial strength (Kappa 0.67 to 0.73; Spearman's rho 0.67 to 0.81). Results on concurrent validity between IPAQ and GPAQ also showed a moderate to strong positive relationship (range 0.45 to 0.65). Results on criterion validity were in the poor-fair (range 0.06 to 0.35). There were some observed differences between sex, education, BMI and urban/rural and between countries. Overall GPAQ provides reproducible data and showed a moderate-strong positive correlation with IPAQ, a previously validated and accepted measure of physical activity. Validation of GPAQ produced poor results although the magnitude was similar to the range reported in other studies. Overall, these results indicate that GPAQ is a suitable and acceptable instrument for monitoring physical activity in population health surveillance systems, although further replication of this work in other countries is warranted.
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                Author and article information

                Contributors
                Journal
                Int J Hypertens
                Int J Hypertens
                IJHY
                International Journal of Hypertension
                Hindawi
                2090-0384
                2090-0392
                2021
                26 November 2021
                : 2021
                : 1482500
                Affiliations
                1Department of Physiology, College of Medicine and Health Sciences, Debre-Tabor University, Debre Tabor, Ethiopia
                2Department of Human Physiology, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia
                Author notes

                Academic Editor: Tomohiro Katsuya

                Author information
                https://orcid.org/0000-0002-4982-2350
                https://orcid.org/0000-0002-1042-497X
                https://orcid.org/0000-0002-1192-3359
                Article
                10.1155/2021/1482500
                8642021
                051e5217-6127-40a9-87f5-5794211252d9
                Copyright © 2021 Deribew Abebaw Abuhay et al.

                This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                : 9 August 2021
                : 11 November 2021
                Funding
                Funded by: University of Gondar
                Categories
                Research Article

                Cardiovascular Medicine
                Cardiovascular Medicine

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