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      Resolving new memories: a critical look at the dentate gyrus, adult neurogenesis, and pattern separation.

      1 , ,
      Neuron
      Elsevier BV

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          Abstract

          Recently, investigation of new neurons in memory formation has focused on a specific function-pattern separation. However, it has been difficult to reconcile the form of separation tested in behavioral tasks with how it is conceptualized according to computational and electrophysiology perspectives. Here, we propose a memory resolution hypothesis that considers the unique information contributions of broadly tuned young neurons and highly specific mature neurons and describe how the fidelity of memories can relate to spatial and contextual discrimination. See the related Perspective from Sahay, Wilson, and Hen, "Pattern Separation: A Common Function for New Neurons in Hippocampus and Olfactory Bulb," in this issue of Neuron.

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          Author and article information

          Journal
          Neuron
          Neuron
          Elsevier BV
          1097-4199
          0896-6273
          May 26 2011
          : 70
          : 4
          Affiliations
          [1 ] Laboratory of Genetics, Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
          Article
          S0896-6273(11)00391-6 NIHMS298402
          10.1016/j.neuron.2011.05.010
          3240575
          21609818
          053254c2-c117-4235-9c6e-d06f26158aad
          Copyright © 2011 Elsevier Inc. All rights reserved.
          History

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