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      Plasma and Pituitary Concentration of Growth Hormone in Male and Female Rats during a 24-Hour Period

      ,

      Hormone Research in Paediatrics

      S. Karger AG

      Plasma GH, Pituitary GH, Circadian rhythm

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          Abstract

          The aim of this study was to investigate the pattern of growth hormone (GH) secretion during a 24-hour period in the rat, in order to determine whether differences in plasma GH between male and female animals could be demonstrated. The daily fluctuations of plasma GH were characterized by three major bursts of secretion occurring at 09.00, 16.30 and 21.00 h in both sexes. In females, the three peaks were of the same extent, while in males the night peak was greater than the other two. Female rats maintained higher GH levels than males at 09.00, 12.00 and 16.30 h, while no differences between both sexes were found at all other times. These results show that sampling time seems to be of great importance in evaluating the differences in plasma GH concentration between experimental groups in which there could be marked differences in the daily patterns of hormone secretion.

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          Author and article information

          Journal
          HRE
          Horm Res Paediatr
          10.1159/issn.1663-2818
          Hormone Research in Paediatrics
          S. Karger AG
          1663-2818
          1663-2826
          1981
          1981
          25 November 2008
          : 14
          : 2
          : 130-137
          Affiliations
          Departamento de Endocrinología Experimental, Instituto ‘G. Marañon’, y Facultad de Medicina de la Universidad Autónoma de Madrid, Madrid, España
          Article
          179369 Horm Res 1981;14:130–137
          10.1159/000179369
          7275002
          © 1981 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 8
          Categories
          Original Paper

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