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Evidence-based and consensus clinical practice guidelines for the iron treatment of restless legs syndrome/Willis-Ekbom disease in adults and children: an IRLSSG task force report
Richard P. Allen ,
Daniel L. Picchietti ,
Michael Auerbach ,
Yong Won Cho ,
James R. Connor ,
Christopher J. Earley ,
Diego Garcia-Borreguero ,
Suresh Kotagal ,
Mauro Manconi ,
William Ondo ,
Jan Ulfberg ,
John W. Winkelman
January 2018
January 2018
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Abstract
Brain iron deficiency has been implicated in the pathophysiology of RLS, and current
RLS treatment guidelines recommend iron treatment when peripheral iron levels are
low. In order to assess the evidence on the oral and intravenous (IV) iron treatment
of RLS and periodic limb movement disorder (PLMD) in adults and children, the International
Restless Legs Syndrome Study Group (IRLSSG) formed a task force to review these studies
and provide evidence-based and consensus guidelines for the iron treatment of RLS
in adults, and RLS and PLMD in children.