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Aspirin Loaded Xerogels for Buccal and Oral Delivery for Patients with Dysphagia to Target Deep Vein Thrombosis

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      This study aimed to develop xerogels for delivery of aspirin via the oral (buccal mucosa and GIT) route in geriatric patients with dysphagia. Xerogels were prepared using low molecular weight chitosan (CS), carrageenan (CAR) and metolose (MET) in different ratios, loaded with aspirin (75 mg). Gels (2.5% w/v and 4.0% w/v) were prepared (60 °C) using 40% v/v ethanol and freeze dried for 48 hours. Xerogels (2.5% w/v MET: CAR 3:1 and 1:1, 4.0% CAR: CS 1:3 and 1:1 and 4.0% MET: CS 1:3 gels) were characterised with texture analysis (TA) for hardness and mucoadhesion, swelling index (%) and porosity (%) to identify an optimised formulation for controlled release (buccal) and fast release (GIT) delivery. Scanning electron microscopy (SEM) was used to assess surface morphology and X-ray diffraction (XRD) to assess the physical form of the formulations (amorphous or crystalline). Xerogels from 2.5 % w/v MET: CAR 3:1 and 1:1 gels showed higher swelling capacity (%) (more than 2 hours to disintegrate) and can be applied to the buccal mucosa for controlled delivery of the API while 4.0 % w/v CAR: CS 1:3 and 1:1 can be used as rapid release xerogel (disintegrated within 2 minutes) for oral GIT delivery.

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      Most cited references 2

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      Polymer films as vehicle for buccal delivery: swelling, mechanical and bioadhesive properties

       Peh,  Wong,  K.K. Peh (1999)
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        Development of innovative orally fast disintegrating film dosage forms: A review

         Panda,  Dey,  Rao (2012)

          Author and article information

          Department of Pharmaceutical, Chemical & Environmental Sciences, Faculty of Engineering and Science, University of Greenwich, Medway Campus, Kent ME4 4TB, United Kingdom
          Author notes
          *Corresponding author. Tel.: +44 0208 331 8980 E-mail: mghimire@
          British Journal of Pharmacy
          University of Huddersfield Press
          11 July 2018
          : 2
          : 2 , Proceedings of the 8 th APS International PharmSci 2017
          : S16-S18
          © 2017, Smirna Farias, Joshua Boateng

          This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY) 4.0

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