2
views
0
recommends
+1 Recommend
1 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Properties of Thermal Analgesia in a Human Chronic Low Back Pain Model

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Purpose

          For years, heat has been used for comfort and analgesia is recommended as a first-line therapy in many clinical guidelines. Yet, there are questions that remain about the actual effectiveness of heat for a condition as common as chronic low back pain, and factors such as time of onset, optimal temperature, and duration of effect.

          Materials and Methods

          A randomized double-blinded controlled trial was designed to compare the analgesic response to heat delivered via pulses at 45°C (experimental group, N=49) to steady heat at 37°C (control group, N=51) in subjects with longstanding low back pain. Treatment lasted 30 minutes with follow-up out to four hours. The hypothesis was that the experimental group would experience a higher degree of analgesia compared to the control group. Time of onset and duration of effect were also measured.

          Results

          Both groups were similar in average duration of pain (10.3 years). The primary outcome measure was pain reduction at 30 minutes after the end of treatment, using a 10-points numeric pain scale. Reduction in pain was greater for the experimental group than the control group (difference in mean reduction = 0.72, 95% CI 0.15–1.29, p = 0.014). Statistically significant differences in pain levels were observed from the first measure at 5 minutes of treatment through 120 minutes after completion of treatment. Reduction in pain associated movement was greater in the active heat group than the placebo group (p = 0.04).

          Conclusion

          High-level pulsed heat (45°C) produced significantly more analgesia as compared to steady heat at 37°C at the primary end point and for an additional 2 hours after treatment. The onset of analgesia was rapid, <5 minutes of treatment. The results of this trial provide insight into the mechanisms and properties of thermal analgesia that are not well understood in a chronic low back pain model.

          Video abstract

          Point your SmartPhone at the code above. If you have a QR code reader the video abstract will appear. Or use:

          https://youtu.be/2wTgVDrQGTQ

          Related collections

          Most cited references 28

          • Record: found
          • Abstract: found
          • Article: not found

          Systemic Pharmacologic Therapies for Low Back Pain: A Systematic Review for an American College of Physicians Clinical Practice Guideline.

          A 2007 American College of Physicians guideline addressed pharmacologic options for low back pain. New evidence and medications have now become available.
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Opioids for Chronic Noncancer Pain

            Harms and benefits of opioids for chronic noncancer pain remain unclear.
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Opioids compared to placebo or other treatments for chronic low-back pain.

              The use of opioids in the long-term management of chronic low-back pain (CLBP) has increased dramatically. Despite this trend, the benefits and risks of these medications remain unclear. This review is an update of a Cochrane review first published in 2007.
                Bookmark

                Author and article information

                Journal
                J Pain Res
                J Pain Res
                jpr
                jpainres
                Journal of Pain Research
                Dove
                1178-7090
                13 August 2020
                2020
                : 13
                : 2083-2092
                Affiliations
                [1 ]Soovu Labs Inc ., Seattle, WA, USA
                [2 ]Department of Health Services, University of Washington , Seattle, WA, USA
                [3 ]Northern California Research , Sacramento, CA, USA
                [4 ]Biology Department, University of Washington , Seattle, WA, USA
                Author notes
                Correspondence: Charles Chabal Soovu Labs Inc ., Seattle, WA, USATel +1 206-579-4910 Email Chuck@Soovu.com
                Article
                260967
                10.2147/JPR.S260967
                7434528
                © 2020 Chabal et al.

                This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License ( http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms ( https://www.dovepress.com/terms.php).

                Page count
                Figures: 3, Tables: 3, References: 35, Pages: 10
                Categories
                Original Research

                Anesthesiology & Pain management

                thermal analgesia, heat, chronic low back pain

                Comments

                Comment on this article