Allan K. Alencar: Role: Data curationRole: InvestigationRole: Methodology
Fábio I. Carvalho: Role: Data curationRole: InvestigationRole: Methodology
Ananssa M. Silva: Role: Data curationRole: InvestigationRole: Methodology
Sabrina T. Martinez: Role: Methodology
Jorge A. Calasans-Maia: Role: Formal analysisRole: MethodologyRole: Validation
Carlos M. Fraga: Role: Formal analysisRole: InvestigationRole: MethodologyRole: Writing – review &
editing
Eliezer J. Barreiro: Role: ConceptualizationRole: Formal analysisRole: Project administrationRole: Writing
– review & editing
Gisele Zapata-Sudo: Role: ConceptualizationRole: Formal analysisRole: InvestigationRole: SupervisionRole:
Writing – original draftRole: Writing – review & editing
Roberto T. Sudo:
ORCID: http://orcid.org/0000-0002-1602-036X
Role: ConceptualizationRole: Formal analysisRole: InvestigationRole: Project administrationRole:
SupervisionRole: Writing – original draftRole: Writing – review & editing
Michael Bader: Role: Editor
Journal ID (nlm-ta): PLoS One
Journal ID (iso-abbrev): PLoS ONE
Journal ID (publisher-id): plos
Journal ID (pmc): plosone
Title:
PLoS ONE
Publisher:
Public Library of Science
(San Francisco, CA USA
)
ISSN
(Electronic):
1932-6203
Publication date
(Electronic):
20
April
2018
Publication date Collection: 2018
Volume: 13
Issue: 4
Electronic Location Identifier: e0195047
Affiliations
[1
]
Programa de Pesquisa em Desenvolvimento de Fármacos, Instituto de Ciências Biomédicas,
Universidade Federal do Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil
[2
]
Instituto de Química, Universidade Federal Fluminense, Rio de Janeiro, Rio de Janeiro,
Brazil
[3
]
Serviço de Anestesiologia, Hospital Universitário, Universidade Federal do Rio de
Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil
Max Delbruck Centrum fur Molekulare Medizin Berlin Buch, GERMANY
Author notes
Competing Interests: The authors have declared that no competing interests exist.
Author information
Article
Publisher ID:
PONE-D-17-42043
DOI: 10.1371/journal.pone.0195047
PMC ID: 5909907
PubMed ID: 29677206
SO-VID: 0584ddcf-0e2b-4e43-b171-5823f0871c9c
Copyright © © 2018 Alencar et al
License:
This is an open access article distributed under the terms of the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided
the original author and source are credited.
Funded by: Instituto Nacional de Ciência e Tecnologia (INCT-INOFAR)
Award ID: 465249/2014-0
Award Recipient
:
ORCID: http://orcid.org/0000-0002-1602-036X
Roberto T. Sudo
Funded by: Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ)
Award Recipient
:
Allan K. Alencar
Funded by: Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Award Recipient
:
Ananssa M. Silva
Funded by: Conselho Nacional de Desenvolvimento Cientifico e Tecnológico (CNPq)
Award Recipient
:
Gisele Zapata-Sudo
Funded by: funder-id http://dx.doi.org/10.13039/501100003593, Conselho Nacional de Desenvolvimento Científico e Tecnológico;
Award Recipient
:
ORCID: http://orcid.org/0000-0002-1602-036X
Roberto T. Sudo
This work was supported by Conselho Nacional de Desenvolvimento Cientifico e Tecnológico
(CNPq) to GZ-S and RTS, Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
(CAPES) to AMS, Programa de Apoio a Núcleos de Experiência (PRONEX), Fundação Carlos
Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ) to AKA, and
the Instituto Nacional de Ciência e Tecnologia (INCT-INOFAR (Proc. 465249/2014-0)
to RTS. The funders had no role in study design, data collection and analysis, decision
to publish, or preparation of the manuscript.
Subject:
Research Article
Subject:
Biology and Life Sciences
Subject:
Anatomy
Subject:
Cardiovascular Anatomy
Subject:
Heart
Subject:
Medicine and Health Sciences
Subject:
Anatomy
Subject:
Cardiovascular Anatomy
Subject:
Heart
Subject:
Medicine and Health Sciences
Subject:
Pharmaceutics
Subject:
Drug Therapy
Subject:
Biology and Life Sciences
Subject:
Anatomy
Subject:
Cardiovascular Anatomy
Subject:
Heart
Subject:
Cardiac Ventricles
Subject:
Medicine and Health Sciences
Subject:
Anatomy
Subject:
Cardiovascular Anatomy
Subject:
Heart
Subject:
Cardiac Ventricles
Subject:
Research and Analysis Methods
Subject:
Experimental Organism Systems
Subject:
Model Organisms
Subject:
Rats
Subject:
Wistar Rats
Subject:
Research and Analysis Methods
Subject:
Model Organisms
Subject:
Rats
Subject:
Wistar Rats
Subject:
Research and Analysis Methods
Subject:
Experimental Organism Systems
Subject:
Animal Models
Subject:
Rats
Subject:
Wistar Rats
Subject:
Biology and Life Sciences
Subject:
Organisms
Subject:
Eukaryota
Subject:
Animals
Subject:
Vertebrates
Subject:
Amniotes
Subject:
Mammals
Subject:
Rodents
Subject:
Rats
Subject:
Wistar Rats
Subject:
Medicine and Health Sciences
Subject:
Diagnostic Medicine
Subject:
Diagnostic Radiology
Subject:
Ultrasound Imaging
Subject:
Echocardiography
Subject:
Research and Analysis Methods
Subject:
Imaging Techniques
Subject:
Diagnostic Radiology
Subject:
Ultrasound Imaging
Subject:
Echocardiography
Subject:
Medicine and Health Sciences
Subject:
Radiology and Imaging
Subject:
Diagnostic Radiology
Subject:
Ultrasound Imaging
Subject:
Echocardiography
Subject:
Biology and Life Sciences
Subject:
Anatomy
Subject:
Cardiovascular Anatomy
Subject:
Blood Vessels
Subject:
Arteries
Subject:
Pulmonary Arteries
Subject:
Medicine and Health Sciences
Subject:
Anatomy
Subject:
Cardiovascular Anatomy
Subject:
Blood Vessels
Subject:
Arteries
Subject:
Pulmonary Arteries
Subject:
Medicine and Health Sciences
Subject:
Pharmacology
Subject:
Routes of Administration
Subject:
Oral Administration
Subject:
Medicine and Health Sciences
Subject:
Pharmaceutics
Subject:
Drug Therapy
Subject:
Drug Administration
