Overview of Albumin and Its Purification Methods

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

<p class="first" id="d11033652e208">As the most frequent plasma protein, albumin constitutes more than 50% of the serum proteins in healthy individuals. It has a key role in oncotic pressure maintenance and it is known as a versatile protein carrier for transportation of various endogenous and exogenous ligands. Reduced amounts of albumin in the body will lead to different kinds of diseases such as hypovolemia and hypoproteinemia. It also has various indications in shocks, burns, cardiopulmonary bypass, acute liver failure and etc. Further applications in research consist of cell culture supplement, drug delivery carrier and protein/drug stabilizer. So, the demand for albumin increased annually worldwide. Due to different applications of albumin, many efforts have been accomplished to achieve albumin during a long period of time. In this review, an overview of serum albumin and different purification methods are summarized. </p>

Related collections

Most cited references 97

Record: found
Abstract: found
Article: not found

Albumin-based nanoparticles as potential controlled release drug delivery systems.

Ahmed Elzoghby, Wael Samy, Nazik A Elgindy (2012)

Albumin, a versatile protein carrier for drug delivery, has been shown to be nontoxic, non-immunogenic, biocompatible and biodegradable. Therefore, it is ideal material to fabricate nanoparticles for drug delivery. Albumin nanoparticles have gained considerable attention owing to their high binding capacity of various drugs and being well tolerated without any serious side-effects. The current review embodies an in-depth discussion of albumin nanoparticles with respect to types, formulation aspects, major outcomes of in vitro and in vivo investigations as well as site-specific drug targeting using various ligands modifying the surface of albumin nanoparticles with special insights to the field of oncology. Specialized nanotechnological techniques like desolvation, emulsification, thermal gelation and recently nano-spray drying, nab-technology and self-assembly that have been investigated for fabrication of albumin nanoparticles, are also discussed. Nanocomplexes of albumin with other components in the area of drug delivery are also included in this review. Copyright © 2011 Elsevier B.V. All rights reserved.

0 comments Cited 371 times – based on 0 reviews      Review now

Record: found
Abstract: not found
Article: not found

Albumin: biochemical properties and therapeutic potential.

Jane R. Evans, Gregory J. Quinlan, Tara G. Martin (2005)

0 comments Cited 234 times – based on 0 reviews      Review now

Record: found
Abstract: found
Article: found

Is Open Access

Specific antioxidant properties of human serum albumin

Myriam Taverna, Anne-Lise Marie, Jean-Paul Mira … (2013)

Human serum albumin (HSA) has been used for a long time as a resuscitation fluid in critically ill patients. It is known to exert several important physiological and pharmacological functions. Among them, the antioxidant properties seem to be of paramount importance as they may be implied in the potential beneficial effects that have been observed in the critical care and hepatological settings. The specific antioxidant functions of the protein are closely related to its structure. Indeed, they are due to its multiple ligand-binding capacities and free radical-trapping properties. The HSA molecule can undergo various structural changes modifying its conformation and hence its binding properties and redox state. Such chemical modifications can occur during bioprocesses and storage conditions of the commercial HSA solutions, resulting in heterogeneous solutions for infusion. In this review, we explore the mechanisms that are responsible for the specific antioxidant properties of HSA in its native form, chemically modified forms, and commercial formulations. To conclude, we discuss the implication of this recent literature for future clinical trials using albumin as a drug and for elucidating the effects of HSA infusion in critically ill patients.

0 comments Cited 148 times – based on 0 reviews      Review now

All references

Author and article information

Journal

Journal ID (publisher-id): APB

Title: Advanced Pharmaceutical Bulletin

Abbreviated Title: Adv Pharm Bull

Publisher: International Society for Phytocosmetic Sciences

ISSN (Print): 2228-5881

ISSN (Electronic): 2251-7308

Publication date Created: December 2016

Publication date (Electronic): December 22 2016

Volume: 6

Issue: 4

Pages: 495-507

Article

DOI: 10.15171/apb.2016.063

PMC ID: 5241407

PubMed ID: 28101456

SO-VID: 05984fe4-a15b-4a0d-9af2-c6bcfba8a7b0

History

Data availability:

Comments

Comment on this article

Cited by 45

See all cited by

Most referenced authors 835

See all reference authors

- Version 1