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      The diagnosis of mild cognitive impairment due to Alzheimer's disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

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          Abstract

          The National Institute on Aging and the Alzheimer's Association charged a workgroup with the task of developing criteria for the symptomatic predementia phase of Alzheimer's disease (AD), referred to in this article as mild cognitive impairment due to AD. The workgroup developed the following two sets of criteria: (1) core clinical criteria that could be used by healthcare providers without access to advanced imaging techniques or cerebrospinal fluid analysis, and (2) research criteria that could be used in clinical research settings, including clinical trials. The second set of criteria incorporate the use of biomarkers based on imaging and cerebrospinal fluid measures. The final set of criteria for mild cognitive impairment due to AD has four levels of certainty, depending on the presence and nature of the biomarker findings. Considerable work is needed to validate the criteria that use biomarkers and to standardize biomarker analysis for use in community settings. Copyright © 2011 The Alzheimer's Association. All rights reserved.

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          Author and article information

          Journal
          ALZ
          Alzheimer's & Dementia
          Alzheimer's & Dementia
          Elsevier BV
          15525260
          May 2011
          May 2011
          April 22 2011
          : 7
          : 3
          : 270-279
          Affiliations
          [1 ]Department of Neurology; Johns Hopkins University School of Medicine; Baltimore MD USA
          [2 ]Office of the Dean, University of Virginia; Charlottesville VA USA
          [3 ]Department of Neurology; University of Virginia; Charlottesville VA USA
          [4 ]Department of Pathology; Mayo Clinic; Jacksonville FL USA
          [5 ]Institute for Memory and Alzheimer's Disease, INSERM Unit Cognition, Neuro-imagerie et maladies due Cerveau, Groupe Hospitalier Pitie-Salpetriere; Paris France
          [6 ]Bristol-Myers Squibb Neuroscience; Wallingford CT USA
          [7 ]Institute of Neurology, University College London; London United Kingdom
          [8 ]Department of Neuroscience; University of California; San Diego CA USA
          [9 ]Department of Neurology; Washington University; St. Louis MO USA
          [10 ]Knight Alzheimer's Disease Research Center, Washington University; St. Louis MO USA
          [11 ]Helen Wills Neuroscience Institute, University of California; Berkeley CA USA
          [12 ]Department of Neurology; Mayo Clinic; Rochester MN USA
          [13 ]Rhode Island Hospital, Alpert Medical School of Brown University; Providence RI USA
          [14 ]Department of Neurology; Alpert Medical School of Brown University; Providence RI USA
          [15 ]Alzheimer's Association; Chicago IL USA
          [16 ]National Institute on Aging; Bethesda MD USA
          Article
          10.1016/j.jalz.2011.03.008
          3312027
          21514249
          059a3e3a-b62f-4f30-be0a-798ebfbe3efa
          © 2011

          http://doi.wiley.com/10.1002/tdm_license_1.1

          http://onlinelibrary.wiley.com/termsAndConditions#vor

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