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      Lack of Detectable Secretion of ACTH from Pituitary Homografts of Pars Intermedia

      , , ,

      Neuroendocrinology

      S. Karger AG

      ACTH, MSH, Pituitary gland, Pars intermedia, Pituitary grafts

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          Abstract

          Hypophysectomized rats bearing grafts of the pars intermedia (PI) in the kidney capsule for 20 days did not show adrenal weights significantly different from those of hypophysectomized controls. Plasma corticosterone was undetectable in the grafted rats, even after the injection of lysine-vasopressin or histamine. On the other hand, MSH activity was present in measurable amounts, independent of the drug administered, in the plasma of the grafted rats. These results suggest that PI transplants do not have the ability to release ACTH, even though it has been previously reported that they contain this hormone.

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          Author and article information

          Journal
          NEN
          Neuroendocrinology
          10.1159/issn.0028-3835
          Neuroendocrinology
          S. Karger AG
          0028-3835
          1423-0194
          1976
          1976
          25 March 2008
          : 22
          : 2
          : 175-182
          Affiliations
          Istituto di Endocrinologia, Universitá di Milano, Milano, and Cátedra ‘B’ de Histología y Embriología, Facultad de Ciencias Medicas, Universidad Nacional de La Plata, La Plata
          Article
          122624 Neuroendocrinology 1976;22:175–182
          10.1159/000122624
          196231
          © 1976 S. Karger AG, Basel

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          Page count
          Pages: 8
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