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Altered GluA1 ( Gria1 ) Function and Accumbal Synaptic Plasticity in the Clock Δ19 Model of Bipolar Mania
Puja K. Parekh ,
Darius Becker-Krail ,
Poornima Sundaravelu ,
Shinsuke Ishigaki ,
Haruo Okado ,
Gen Sobue ,
Yanhua Huang ,
Colleen A. McClung
June 2017
June 2017
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Abstract
Disruptions in circadian rhythms are associated with an increased risk for bipolar
disorder. Moreover, studies show that the circadian protein CLOCK (circadian locomotor
output cycles kaput) is involved in regulating monoaminergic systems and mood-related
behavior. However, the molecular and synaptic mechanisms underlying this relationship
remain poorly understood.