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      Juvenile idiopathic arthritis.

      1 , 2
      Lancet (London, England)
      Elsevier BV

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          Abstract

          Juvenile idiopathic arthritis is a broad term that describes a clinically heterogeneous group of arthritides of unknown cause, which begin before 16 years of age. This term encompasses several disease categories, each of which has distinct methods of presentation, clinical signs, and symptoms, and, in some cases, genetic background. The cause of disease is still poorly understood but seems to be related to both genetic and environmental factors, which result in the heterogeneity of the illness. Although none of the available drugs has a curative potential, prognosis has greatly improved as a result of substantial progresses in disease management. The most important new development has been the introduction of drugs such as anticytokine agents, which constitute a valuable treatment option for patients who are resistant to conventional antirheumatic agents. Further insights into the disease pathogenesis and treatment will be provided by the continuous advances in understanding of the mechanisms connected to the immune response and inflammatory process, and by the development of new drugs that are able to inhibit selectively single molecules or pathways.

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          Author and article information

          Journal
          Lancet
          Lancet (London, England)
          Elsevier BV
          1474-547X
          0140-6736
          Mar 03 2007
          : 369
          : 9563
          Affiliations
          [1 ] Department of Paediatrics, University of Genoa and Institute G. Gaslini, Genoa, Italy. Electronic address: angeloravelli@ospedale-gaslini.ge.it.
          [2 ] Department of Paediatrics, University of Genoa and Institute G. Gaslini, Genoa, Italy.
          Article
          S0140-6736(07)60363-8
          10.1016/S0140-6736(07)60363-8
          17336654
          05a107a1-74f0-4995-99c2-2b17f50c4740
          History

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