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      A systematic evaluation of hydroxyethyl starch as a potential nanocarrier for parenteral drug delivery.

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          Abstract

          Development of parenteral nanoformulations is highly challenging due to the stringent demands on stability, reproducibility and high drug loading with minimal excipients. This study focuses on the development of a pharmaceutically acceptable nanomatrix system for parenteral delivery based on Hydroxyethyl Starch (HES), a FDA approved polymer that is relatively unexplored in drug delivery research. HES nanoparticles were prepared through a simple, two-step crosslinking-precipitation route, yielding 160±5 nm, nearly monodispersed spherical particles with high colloidal stability. The utility of this nanocarrier for parenteral delivery was verified by a panel of hemo/cytocompatibility assays at high concentrations (0.05-1 mg/ml) in vitro and in vivo. HES nanomatrix was found effective in encapsulating two chemically distinct drugs having varying hydrophobicities, with the release behavior being influenced by their chemical nature and drug-matrix interactions. Better in vitro efficacy was measured for the nanoencapsulated drug than its bare form, establishing the potential of HES nanocarriers for controlled drug delivery.

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          Author and article information

          Journal
          Int. J. Biol. Macromol.
          International journal of biological macromolecules
          Elsevier BV
          1879-0003
          0141-8130
          Mar 2015
          : 74
          Affiliations
          [1 ] Amrita Centre for Nanosciences & Molecular Medicine, Amrita Institute of Medical Sciences & Research Centre, Amrita Vishwa Vidyapeetham, Kochi 682 041, Kerala, India.
          [2 ] Amrita Centre for Nanosciences & Molecular Medicine, Amrita Institute of Medical Sciences & Research Centre, Amrita Vishwa Vidyapeetham, Kochi 682 041, Kerala, India. Electronic address: deepthymenon@aims.amrita.edu.
          Article
          S0141-8130(14)00816-2
          10.1016/j.ijbiomac.2014.12.012
          25572720

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