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      The SWI/SNF complex and cancer.

      1 , ,
      Oncogene
      Springer Science and Business Media LLC

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          Abstract

          The mammalian SWI/SNF complexes mediate ATP-dependent chromatin remodeling processes that are critical for differentiation and proliferation. Not surprisingly, loss of SWI/SNF function has been associated with malignant transformation, and a substantial body of evidence indicates that several components of the SWI/SNF complexes function as tumor suppressors. This review summarizes the evidence that underlies this conclusion, with particular emphasis upon the two catalytic subunits of the SWI/SNF complexes, BRM, the mammalian ortholog of SWI2/SNF2 in yeast and brahma in Drosophila, and Brahma-related gene-1 (BRG1).

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          Author and article information

          Journal
          Oncogene
          Oncogene
          Springer Science and Business Media LLC
          1476-5594
          0950-9232
          Apr 09 2009
          : 28
          : 14
          Affiliations
          [1 ] Department of Internal Medicine, University of Michigan College of Medicine, Ann Arbor, MI 48109-0686, USA. dreisman@med.umich.edu
          Article
          onc20094
          10.1038/onc.2009.4
          19234488
          05bc4065-8e05-4b62-8e4a-f6b61c95993b
          History

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