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      Subcutaneous Fat Fibrosis Links Obesity to Insulin Resistance in Chinese Americans

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          Abstract

          <div class="section"> <a class="named-anchor" id="s1"> <!-- named anchor --> </a> <h5 class="section-title" id="d4670919e207">Objective</h5> <p id="d4670919e209">Type 2 diabetes presents at a lower body mass index (BMI) in Chinese individuals than in white individuals. We sought to determine the role of subcutaneous adipose tissue (SCAT)–intrinsic factors, vs BMI or adiposity <i>per se</i>, in the vulnerability of Chinese individuals to obesity-associated impairment of insulin sensitivity. </p> </div><div class="section"> <a class="named-anchor" id="s2"> <!-- named anchor --> </a> <h5 class="section-title" id="d4670919e215">Research Design and Methods</h5> <p id="d4670919e217">Thirty-two Chinese and 30 white men and women from a cohort in the San Francisco Bay Area underwent anthropometric measurements, body composition (dual-energy X-ray absorptiometry) analyses, and measurement of fasting plasma glucose and insulin. Forty-eight also provided abdominal SCAT samples for transcriptional and biochemical analyses of tissue fibrosis. </p> </div><div class="section"> <a class="named-anchor" id="s3"> <!-- named anchor --> </a> <h5 class="section-title" id="d4670919e220">Results</h5> <p id="d4670919e222">BMI correlated with total body fat in white ( <i>r</i> = 0.74, <i>P</i> &lt; 0.001) but not Chinese individuals, whereas BMI correlated with visceral adipose tissue (VAT) accrual in both ethnicities ( <i>r</i> = 0.88 and 0.81, respectively; <i>P</i> &lt; 0.01). Insulin resistance (homeostatic model assessment of insulin resistance) worsened with VAT mass, but not total body fat, in Chinese subjects ( <i>r</i> = 0.63, <i>P</i> &lt; 0.01), whereas it worsened with both in white individuals. By contrast, SCAT mRNA levels of genes encoding profibrotic proteins rose remarkably along with both BMI and VAT mass in Chinese but not white subjects. Similarly, SCAT levels of hydroxyproline, an indicator of tissue collagen content that correlated with increasing VAT mass, were higher in Chinese vs white subjects, particularly in the setting of relative insulin resistance. </p> </div><div class="section"> <a class="named-anchor" id="s4"> <!-- named anchor --> </a> <h5 class="section-title" id="d4670919e244">Conclusions</h5> <p id="d4670919e246">Our findings dissociate BMI from adiposity in Chinese individuals and instead highlight SCAT fibrosis as a process linked to visceral adiposity and insulin resistance in this group. </p> </div><p class="first" id="d4670919e249">Here, we show that BMI does not mark adiposity in Chinese-Americans but instead that subcutaneous fat fibrosis correlates with both visceral obesity and reduced glucose control in this population. </p>

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          Author and article information

          Journal
          The Journal of Clinical Endocrinology & Metabolism
          The Endocrine Society
          0021-972X
          1945-7197
          September 2018
          September 01 2018
          May 28 2018
          September 2018
          September 01 2018
          May 28 2018
          : 103
          : 9
          : 3194-3204
          Affiliations
          [1 ]Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of California, San Francisco, San Francisco, California
          [2 ]Diabetes Center, University of California, San Francisco, San Francisco, California
          [3 ]Department of Surgery, University of California, San Francisco, San Francisco, California
          [4 ]Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California
          [5 ]Endocrine Research Unit, San Francisco Veterans Affairs Medical Center, San Francisco, California
          [6 ]Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California
          Article
          10.1210/jc.2017-02301
          6126891
          29846621
          05bd5aa5-e4bb-4aed-8f85-4453545e502f
          © 2018
          History

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