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      Family history of substance use disorders: Significance for mental health in young adults who gamble

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          Abstract

          Background

          Although family history of psychiatric disorders has often been considered potentially useful in understanding clinical presentations in patients, it is less clear what a positive family history means for people who gamble in the general community. We sought to understand the clinical and cognitive impact of having a first-degree relative with a substance use disorder (SUD) in a sample of non-treatment seeking young adults.

          Methods

          576 participants (aged 18–29 years) who gambled at least five times in the preceding year undertook clinical and neurocognitive evaluations. Those with a first-degree relative with a SUD were compared to those without on a number of demographic, clinical and cognitive measures. We used Partial Least Squares (PLS) regression to identify which variables (if any) were significantly associated with family history of SUDs, controlling for the influence of other variables on each other.

          Results

          180 (31.3%) participants had a first-degree family member with a SUD. In terms of clinical variables, family history of SUD was significantly associated with higher rates of substance use (alcohol, nicotine), higher rates of problem gambling, and higher occurrence of mental health disorders. Family history of SUD was also associated with more set-shifting problems (plus higher rates of obsessive-compulsive tendencies), lower quality of decision-making, and more spatial working memory errors.

          Conclusions

          These results indicate that gamblers with a first-degree family member with a SUD may have a unique clinical and cognition presentation. Understanding these differences may be relevant to developing more individualized treatment approaches for disordered gambling. Compulsivity may be important as a proxy of vulnerability towards addiction.

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          Author and article information

          Contributors
          Journal
          2006
          Journal of Behavioral Addictions
          J Behav Addict
          Akadémiai Kiadó (Budapest )
          2062-5871
          2063-5303
          June 2020
          05 June 2020
          : 9
          : 2
          : 289-297
          Affiliations
          [1 ] deptDepartment of Psychiatry & Behavioral Neuroscience , University of Chicago, Chicago, IL, USA
          [2 ] deptDepartment of Psychiatry , University of Cambridge, Cambridge, UK
          [3 ] Cambridge and Peterborough NHS Foundation Trust (CPFT) , Cambridge, UK
          Author notes
          [* ]Corresponding author. deptDepartment of Psychiatry & Behavioral Neuroscience , University of Chicago, Pritzker School of Medicine, 5841 S. Maryland Avenue, MC-3077, Chicago, IL, 60637, USA. Tel.: +1 773 834 1325; fax: +1 773 834 6761 E-mail: jgrant4@ 123456bsd.uchicago.edu
          Article
          10.1556/2006.2020.00017
          7115917
          32516117
          © 2020 The Author(s)

          Open Access statement. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium for non-commercial purposes, provided the original author and source are credited, a link to the CC License is provided, and changes – if any – are indicated.

          Page count
          Figures: 01, Tables: 01, References: 57, Pages: 09
          Product
          Self URI (journal page): https://akademiai.com/loi/2006
          Funding
          Funded by: National Center for Responsible Gaming
          Funded by: Wellcome Trust Clinical Fellowship
          Award ID: 110049/Z/15/Z
          Categories
          Full-length Report

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