In order to explore optimal strategies for managing potential human risk factors, this paper developed an interactive model among potential human risk factors based on the development processes of accidents. This model was divided into four stages, i.e., risk latency stage, risk accumulation stage, risk explosion stage and risk residue stage. Based on this model, this paper analyzed risk management procedures and relevant personal’s responsibility in each stage, and then probed into the interactive mechanism among human risk factors in three aspects, i.e., knowledge, information and communication. The validity and feasibility of the model was validated by analyzing a coal mine roof accident in China. In addition, the contribution of different functional levels’ personnel in risk evolution was discussed. It showed that this model can effectively reveal the interactive mechanism of potential human risk factors, and can thus give significant insights into the development of risk management theories and practices. It also proves that the contribution of different functional levels’ personnel in the model is different. This can further help practitioners design enhanced Behavioral-Based Safety (BBS) intervention approaches which can have a more sustainable and persistent impact on corporate personnel’s safety behavior. Specific recommendations and suggestions are provided fundamentally for future BBS practices in the coal mine industry.