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      [Role of PGE2 in bone metastatic cancer].

      1 ,

      Clinical calcium

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          Abstract

          Prostaglandin E(2) is a crucial mediator to maintain physiological homeostasis and several disease progression. In this article, we summarized the roles of PGE(2) in bone resorptive metastatic model using B16 melanoma. An antagonist of EP4, a receptor subtype for PGE(2), suppressed RANKL expression in osteoblast and following osteoclast formation that was induced by B16, suggesting cancer induced bone resorption mediate PGE(2) production in host osteoblast is a key role of cancer metastasis to bone.

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          Author and article information

          Journal
          Clin Calcium
          Clinical calcium
          0917-5857
          0917-5857
          Apr 2008
          : 18
          : 4
          Affiliations
          [1 ] Tokyo University of Agriculture and Technology, Department of Biotechnology and Life Science.
          0804466472
          CliCa0804466472
          18379028

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