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      Functional topography of the corpus callosum investigated by DTI and fMRI.

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          Abstract

          This short review examines the most recent functional studies of the topographic organization of the human corpus callosum, the main interhemispheric commissure. After a brief description of its anatomy, development, microstructure, and function, it examines and discusses the latest findings obtained using diffusion tensor imaging (DTI) and tractography (DTT) and functional magnetic resonance imaging (fMRI), three recently developed imaging techniques that have significantly expanded and refined our knowledge of the commissure. While DTI and DTT have been providing insights into its microstructure, integrity and level of myelination, fMRI has been the key technique in documenting the activation of white matter fibers, particularly in the corpus callosum. By combining DTT and fMRI it has been possible to describe the trajectory of the callosal fibers interconnecting the primary olfactory, gustatory, motor, somatic sensory, auditory and visual cortices at sites where the activation elicited by peripheral stimulation was detected by fMRI. These studies have demonstrated the presence of callosal fiber tracts that cross the commissure at the level of the genu, body, and splenium, at sites showing fMRI activation. Altogether such findings lend further support to the notion that the corpus callosum displays a functional topographic organization that can be explored with fMRI.

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          Author and article information

          Journal
          World J Radiol
          World journal of radiology
          1949-8470
          Dec 28 2014
          : 6
          : 12
          Affiliations
          [1 ] Mara Fabri, Chiara Pierpaoli, Paolo Barbaresi, Dipartimento di Medicina Sperimentale e Clinica, Sezione di Neuroscienze e Biologia Cellulare, Università Politecnica delle Marche, 60020 Ancona, Italy.
          Article
          10.4329/wjr.v6.i12.895
          4278150
          25550994
          063d78a7-98bc-4830-8d93-9a64069de0b0
          History

          Brain imaging,Corpus callosum,Functional magnetic resonance imaging and diffusion tensor imaging,Interhemispheric transfer,Topographic organization

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