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      Esmolol inhibits inflammation and apoptosis in the intestinal tissue via the overexpression of NF-κB-p65 in the early stage sepsis rats

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          Abstract

          Background/Aims

          Accumulating evidence reveals esmolol could protect the gut mucosa through the regulation of immune response and inflammation in patients with sepsis. However, its underlying mechanism is not fully understood.

          Materials and Methods

          Diamine oxidase (DAO), intestinal fatty acid-binding protein (I-FABP), interleukin (IL)-6, and IL-10 in the plasma of rats were detected by ELISA assay. Western blotting was utilized to measure the expression levels of NF-kappa B-p65, Bcl-2, and cleaved caspase-3 in the intestinal tissues. The survival analysis was performed in each group.

          Results

          The plasma levels of DAO and IL-10 levels were increased, whereas that of I-FABP and IL-6 were decreased in the sepsis rats after esmolol treatment, indicating that after the esmolol treatment, the intestinal inflammation and damages were remarkably reduced as compared to those in the normal saline treated sepsis rats. NF-κB-p65 and Bcl-2 were highly expressed, but cleaved caspase-3 showed lower expression in the esmolol treated groups. However, at the same time, we observed contrasting results in the normal saline treated group. Western blotting data indicated that the esmolol treatment inhibited the inflammation and apoptosis in the intestinal tissue due to the overexpression of NF-κB-p65 in the celiac sepsis rats. The survival analysis results indicate that the esmolol infusion should be used in the early stages sepsis rats.

          Conclusion

          Esmolol can suppress inflammation and apoptosis in the intestinal tissue via the overexpression of NF-kappa B-p65 in the early stage sepsis rats. kappa BEarly-stage use of esmolol might be an ideal treatment method for sepsis.

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          Author and article information

          Journal
          Turk J Gastroenterol
          Turk J Gastroenterol
          TJG
          The Turkish Journal of Gastroenterology
          Turkish Society of Gastroenterology
          1300-4948
          2148-5607
          April 2020
          01 April 2020
          : 31
          : 4
          : 331-341
          Affiliations
          [1 ]Second Clinical Medical College, Lanzhou University, Gansu Province, China
          [2 ]First Aid Center, Lanzhou University Second Hospital, Gansu Province, China
          [3 ]Department of General Surgery, The 940th Hospital of Joint Logistics Support Force of Chinese People’s Liberation Army, China
          [4 ]Intensive Care Unit, Lanzhou University Second Hospital, Gansu Province, China
          [5 ]Department of Pathology, Lanzhou University Second Hospital, Gansu Province, China
          Author notes
          Corresponding Author: Li Ma, Hong-Bin Liu; mali1105@ 123456126.com ; liuhongbin999@ 123456163.com
          Author information
          https://orcid.org/0000-0001-7199-8136
          https://orcid.org/0000-0002-5665-384X
          https://orcid.org/0000-0002-7926-2358
          https://orcid.org/0000-0003-3417-9259
          https://orcid.org/0000-0002-7649-6976
          https://orcid.org/0000-0002-1993-7966
          https://orcid.org/0000-0003-4511-3626
          https://orcid.org/0000-0001-7502-8911
          Article
          PMC7236645 PMC7236645 7236645 tjg-31-3-331
          10.5152/tjg.2020.19341
          7236645
          32412904
          063e7099-2586-4e00-ad72-eeffdfbdaf6d
          Copyright 2020 by Turkish Society of Gastroenterology
          History
          : 15 May 2019
          : 09 July 2019
          Categories
          Original Article
          Basic&Translational

          NF-kappa B,Esmolol,intestine,sepsis,apoptosis
          NF-kappa B, Esmolol, intestine, sepsis, apoptosis

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