Recent Advances in Catalytic Enantioselective Fluorination Reactions

Lectard, Sylvain; Hamashima, Yoshitaka; Sodeoka, Mikiko

doi:10.1002/adsc.201000624

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Recent Advances in Catalytic Enantioselective Fluorination Reactions

Author(s): Sylvain Lectard , Yoshitaka Hamashima , Mikiko Sodeoka

Publication date Created: November 02 2010

Publication date (Print): November 02 2010

Journal: Advanced Synthesis & Catalysis

Publisher: Wiley-Blackwell

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Fluorine in medicinal chemistry.

Sophie Purser, Peter R. Moore, Steve Swallow … (2008)

It has become evident that fluorinated compounds have a remarkable record in medicinal chemistry and will play a continuing role in providing lead compounds for therapeutic applications. This tutorial review provides a sampling of renowned fluorinated drugs and their mode of action with a discussion clarifying the role and impact of fluorine substitution on drug potency.