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      Present Status of Renal Cell Carcinoma in Dialysis Patients in Japan: Questionnaire Study in 2002

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          Abstract

          Aims: To determine the incidence and recent trends of renal cell carcinoma (RCC) in dialysis patients, a nationwide investigation was performed in Japan. Methods: In February 2002, 3,155 questionnaires were sent to dialysis units in Japan. The variables studied for RCC diagnosed between March 2000 and February 2002 included patient age, duration of dialysis, diagnostic aids, cancer size, histology of cancer, and the presence of metastasis and acquired cysts. Results: 489 RCCs (381 males, 104 females, and 4 unknown) were studied. The mean age of the RCC patients was 57.5 ± 11.4 (mean ± SD) years, and the mean duration of dialysis was 136.9 ± 95.2 months. RCC was detected by symptoms alone in 5.3% of the cases, by sonographic screening in 46.1%, and computed tomographic screening in 44.2%. The metastasis rate was 15.2%. The standardized incidence ratio was 9.7 (95% confidence interval, CI: 8.3–11.2) for the male dialysis patients and 11.0 (95% CI: 8.2–14.4) for the female patients. Eighty-four of the RCC patients with more than 20 years of hemodialysis were younger, were more frequently male, and demonstrated a larger cancer size, a higher incidence of papillary RCC, a higher metastasis rate, and a higher incidence of fatal RCC than 215 patients with less than 10 years of dialysis. Conclusion: 54.6% of the patients with RCC received dialysis for more than 10 years. For RCC patients with more than 20 years of dialysis, the mean age was younger, and the metastasis rate was higher than for RCC patients with less than 10 years of dialysis.

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          Author and article information

          Journal
          NEC
          Nephron Clin Pract
          10.1159/issn.1660-2110
          Nephron Clinical Practice
          S. Karger AG
          1660-2110
          2004
          May 2004
          17 November 2004
          : 97
          : 1
          : c11-c16
          Affiliations
          Division of Nephrology, Department of Internal Medicine, Kanazawa Medical University, Ishikawa, Japan
          Article
          77590 Nephron Clin Pract 2004;97:c11–c16
          10.1159/000077590
          15153762
          © 2004 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Figures: 4, Tables: 2, References: 24, Pages: 1
          Product
          Self URI (application/pdf): https://www.karger.com/Article/Pdf/77590
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