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      Interrupted therapy: stopping and switching of the beta-interferons prescribed for MS.

      Neurology

      Adjuvants, Immunologic, Treatment Failure, Retrospective Studies, therapeutic use, administration & dosage, Peptides, drug therapy, Multiple Sclerosis, Middle Aged, Male, adverse effects, Interferon-beta, Injections, Subcutaneous, Injections, Intramuscular, Humans, Female, etiology, Drug-Induced Liver Injury, Drug Utilization, Drug Administration Schedule, Culture, Adult, Adolescent

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          Abstract

          A retrospective chart review of patients in British Columbia with multiple sclerosis prescribed beta-interferon (IFNbeta) between 1995 and 2001 was carried out to investigate reasons for the interruption of therapy. The highest proportion of interruptions (76/281; 27%) occurred in the first 6 months. The single most common reason was perceived lack of efficacy, cited by 84 of 281 (30%). Gender, disability, and disease duration were identified as factors influencing interruption of IFNbeta therapy.

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          12939437

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