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      Evaluation of analgesic, antipyretic and anti-inflammatory activity on Cordia dichotoma G. Forst. Leaf

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          Abstract

          Background:

          Cordia dichotoma G. Forst. is an important medicinal plant of family Boraginaceae. Traditionally, its leaves are used to treat fever, headache, and joint pain but its medicinal activities have not been proven by research.

          Objective:

          To evaluate the analgesic, anti-inflammatory, and antipyretic activity of C. dichotoma G. Forst. leaf extract.

          Material and Methods:

          The various extracts of leaf powder were prepared by using soxhlet apparatus. The methanol extract was selected for pharmacological study. To evaluate analgesic activity, Eddy's hot plate method, to study anti-inflammatory activity, carageenan-induced rat paw edema method, and to study antipyretic activity, yeast-induced pyrexia method was used. SD female rats (180-200 g) were used for the study.

          Results:

          In all three tests, the methanol extract high dose (400 mg/kg) was found to be highly significant as compared to standard drug.

          Conclusion:

          This study proved the traditional uses of plant leaves and concluded the analgesic, anti-inflammatory, and antipyretic activity of the leaf methanol extract.

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          Most cited references17

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          Phytochemical Methods

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            Trease and Evan›s Pharmacognosy

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              Anticonvulsant, analgesic and antipyretic activities of Taxus wallichiana Zucc.

              Taxus wallichiana Zucc. (Himalayan Yew) is often used in northern areas of Pakistan for the treatment of pyrexia, acute pains and epilepsy. We have investigated certain pharmacological activities of the methanol leaf extract against convulsion, nociception and pyrexia induced in rodents. The aim was to justify and explore its folk uses in these pathological conditions, on scientific basis. The studies were carried out using acetic acid-induced nociception and pentylenetetrazole-induced convulsions in mice, while formalin test and yeast-induced pyrexia in rats. Significant analgesic (67.77 and 74.29%) effect was found in acetic acid-induced model at doses of 100 and 200mg/kg, i.p. respectively. Crude extract exhibited significant (P<0.05) inhibition of the formalin noxious stimulation on both early and late phases of pain by the extracts (100 and 200mg/kg doses). In case of yeast-induced pyrexia model, 200mg/kg dose showed very significant (P<0.01) inhibition while 50 and 100mg/kg dose caused a significant (P<0.05) inhibition. Plant extract has controlled the pentylenetetrazole-induced convulsions in mice. 100 and 200mg/kg i.p doses of the extract significantly (P<0.05) inhibited the mioclonus and clonus while inhibition of tonus and hind limb tonic extension (HLTE) was highly significant (P<0.01). The anticonvulsant activity of this plant has been reported for the first time throughout the whole genus. The observed pharmacological activities provide the scientific basis for the folkloric use of the plant in treating epilepsy, pyrexia and acute pain.
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                Author and article information

                Journal
                Pharmacognosy Res
                Pharmacognosy Res
                PR
                Pharmacognosy Research
                Medknow Publications & Media Pvt Ltd (India )
                0976-4836
                0974-8490
                Jan-Mar 2015
                : 7
                : 1
                : 126-130
                Affiliations
                [1] Department of Pharmacognosy, Amar Shaheed Baba Ajit Singh Jujhar Singh Memorial College of Pharmacy, Bela (Ropar), Punjab, India
                Author notes
                Address for correspondence: Ms. Richa Gupta, Department of Pharmacognosy, Amar Shaheed Baba Ajit Singh Jujhar Singh Memorial College of Pharmacy, Bela (Ropar) - 140 111, Punjab, India. E-mail: richa25_gupta@ 123456yahoo.com
                Article
                PR-7-126
                10.4103/0974-8490.147227
                4285642
                25598647
                06ae04c2-1eb5-4e4e-a372-1aa85db4432c
                Copyright: © Pharmacognosy Research

                This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                : 30 May 2014
                : 13 July 2014
                : 17 December 2014
                Categories
                Original Article

                Pharmacology & Pharmaceutical medicine
                analgesic,anti-inflammatory,antipyretic,boraginaceae,cordia dichotoma

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