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      Primary angiitis of the central nervous system: diagnostic criteria.

      1
      Neurologic clinics
      Elsevier BV
      CNS angiitis, CNS vasculitis, Primary angiitis of the central nervous system

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          Abstract

          Primary angiitis of the central nervous system (PACNS) is a vasculitis of small arteries and veins of unknown cause restricted to the central nervous system (CNS), and controversy and disagreement exist over the means to establish the diagnosis. Cerebral arteriography, cerebrospinal fluid examination, and MRI singly or in combination do not have sufficiently demonstrated positive predictive value to establish the diagnosis. An alternative diagnosis is established at biopsy in 35% of cases. Histologic confirmation is required for the diagnosis of PACNS. Patients without histologic confirmation should not be included in case reports, case series, or reviews.

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          Author and article information

          Journal
          Neurol Clin
          Neurologic clinics
          Elsevier BV
          1557-9875
          0733-8619
          May 2015
          : 33
          : 2
          Affiliations
          [1 ] Department of Neurology, University of North Carolina at Chapel Hill, Room 2131, CB #7025, 170 Manning Drive, Chapel Hill, NC 27514, USA. Electronic address: powersw@neurology.unc.edu.
          Article
          S0733-8619(14)00120-0
          10.1016/j.ncl.2014.12.004
          25907920
          06cacc33-717e-47e4-9301-c8de302bb1e4
          History

          CNS angiitis,CNS vasculitis,Primary angiitis of the central nervous system

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