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      Cell Biology of Astrocyte-Synapse Interactions

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      Neuron
      Elsevier BV

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          Abstract

          <p class="first" id="P1">Astrocytes, the most abundant glial cells in the mammalian brain, are critical regulators of brain development and physiology through dynamic and often bidirectional interactions with neuronal synapses. Despite the clear importance of astrocytes for the establishment and maintenance of proper synaptic connectivity, our understanding of their role in brain function is still in its infancy. We propose that this is at least in part due to large gaps in our knowledge of the cell biology of astrocytes and the mechanisms they use to interact with synapses. In this review, we summarize some of the seminal findings that yield important insight into the cellular and molecular basis of astrocyte-neuron communication, focusing on the role of astrocytes in the development and remodeling of synapses. Furthermore, we will pose some pressing questions that need to be addressed to advance our mechanistic understanding of the role of astrocytes in regulating synaptic development. </p>

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          Author and article information

          Journal
          Neuron
          Neuron
          Elsevier BV
          08966273
          November 2017
          November 2017
          : 96
          : 3
          : 697-708
          Article
          10.1016/j.neuron.2017.09.056
          5687890
          29096081
          06d2674a-e4e4-4336-9218-33398996f61e
          © 2017

          http://www.elsevier.com/tdm/userlicense/1.0/

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