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Gene therapy for psoriasis in the K14-VEGF transgenic mouse model by topical transdermal delivery of interleukin-4 using ultradeformable cationic liposome.
Jiong Li
1 ,
Xia Li ,
Yan Zhang ,
Xi K Zhou ,
Han S Yang ,
Xian C Chen ,
Yong S Wang ,
Yu Q Wei ,
Li J Chen ,
Huo Z Hu ,
Chang Y Liu
Jun 2010
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Abstract
Topical transdermal gene delivery to the skin shows great potential for painless, non-invasive administration of vaccines and therapeutic agents. Interleukin (IL)-4 strategies have shown a good antipsoriatic effect in clinic trials. To date, no information has been acquired on the effectiveness of gene therapy for psoriasis in the K14-VEGF transgenic mouse model by topical transdermal penetration of murine IL-4 (mIL-4) using ultradeformable cationic liposome (UCL).