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      Three new alkaloids isolated from the stem tuber of Pinellia pedatisecta

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          Abstract

          The present study was designed to determine the chemical constituents of the stem tuber of Pinellia pedatisecta. The chemical constituents were isolated and purified by various chromatographic techniques, and their structures were elucidated on the basis of physicochemical properties and spectral data. Three new alkaloids (compounds 1, 2, and 3) were obtained and identified as 9-((5-methoxypyridin-2-yl)methyl)-9 H-purin-6-amine ( 1), 4-(2-(2, 5-dioxopyrrolidin-1-yl)ethyl)phenyl acetate ( 2), and N-(9-((5- me-thoxypyridin-2-yl)methyl)-9 H-purin-6-yl)acetamide ( 3). These compounds were evaluated for their cytotoxicity against human cervical cancer HeLa cells. Compounds 1 and 3 significantly inhibited the proliferation of HeLa cells with IC 50 values being 3.02 � 0.54 and 7.16 � 0.62 μmol·L –1, respectively.

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          Author and article information

          Journal
          CJNM
          Chinese Journal of Natural Medicines
          Elsevier
          1875-5364
          20 February 2018
          : 16
          : 2
          : 139-142
          Affiliations
          1School of Chemical Engineering, Institute of Pharmaceutical Engineering Technology and Application, Key Laboratory of Green Chemistry of Sichuan Institutes of Higher Education, Sichuan University of Science & Engineering, Zigong 643000, China
          2Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
          3Institute of Interdisciplinary Integrative Biomedical Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
          Author notes
          *Corresponding authors: LIU Xuan, Tel: 86-21-68383952, E-mails: 13764960370@ 123456163.com ; CHENG Chun-Ru, pharmaceutics@ 123456163.com

          These authors have no conflict of interest to declare.

          Article
          S1875-5364(18)30040-2
          10.1016/S1875-5364(18)30040-2
          Copyright © 2018 China Pharmaceutical University. Published by Elsevier B.V. All rights reserved.
          Funding
          Funded by: National Natural Science Foundation of China
          Award ID: 81373964
          Funded by: Introduction Program of Scientific Researcher of Sichuan University of Science & Engineering
          Award ID: 2016RCL07
          Award ID: 2017RCL61
          Funded by: Key Laboratory of Green Chemistry of Sichuan Institutes of Higher Education
          Award ID: LYJ1302
          Funded by: Scientific Research Fund of the Sichuan Provincial Education Department
          Award ID: 13ZB0133
          Funded by: Science and Technology Program Project of Sichuan
          Award ID: 2015JY0024
          This work was supported by the National Natural Science Foundation of China (No. 81373964), Introduction Program of Scientific Researcher of Sichuan University of Science & Engineering (Nos. 2016RCL07 and 2017RCL61), the Opening Project of Key Laboratory of Green Chemistry of Sichuan Institutes of Higher Education (No. LYJ1302), the Scientific Research Fund of the Sichuan Provincial Education Department (No. 13ZB0133), and the Science and Technology Program Project of Sichuan (No. 2015JY0024).

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