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      Brain and platelet serotonin transporter in humans-correlation between [123I]-ADAM SPECT and serotonergic measurements in platelets.

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          Abstract

          Blood platelets are thought to be a useful peripheral model for investigating the central serotoninergic mechanisms associated with the serotonin transporter (SERT). On the other hand, an in vivo investigation of SERT in the human brain has been made possible by the development of several promising SPECT radioligands, such as [123I]-ADAM. The aim of the present study was to investigate the possible correlation between the SERT measurements in the brain and those in platelets. Forty-four subjects (14 healthy subjects and 30 patients with the diagnosis of major depression or schizoaffective disorder) were examined. The [123I]-ADAM binding was assessed 4h after injection using MR-guided regions of interest (ROIs) in the midbrain and cerebellum. In a parallel investigation, serotonin (5HT) concentration and kinetic characteristics of 5HT uptake activity (Vmax and Km) were determined in platelet-rich plasma. Overall, there was no significant correlation between the V(max) of 5HT uptake in platelets and the specific to nonspecific partition coefficient of [123I]-ADAM (V''3) in the midbrain. However, low but significant Pearson correlation coefficients were found for V(max) and normalised activities measured in the midbrain (r=0.310, p=0.043). The correlation was stronger and significant in females (n=20, r=0.629, p=0.003) but low and non-significant in the 24 males (r=0.104). Although confirmation is necessary, it seems that the relationship between different indices of [123I]-ADAM binding in the brain and 5HT uptake characteristics in platelets is complex, nonuniform, and possibly gender-specific.

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          Author and article information

          Journal
          Neurosci. Lett.
          Neuroscience letters
          Elsevier BV
          0304-3940
          0304-3940
          Oct 09 2006
          : 406
          : 3
          Affiliations
          [1 ] Department of Psychiatry and Psychotherapy, Campus Mitte, Charité, Universitätsmedizin Berlin, Berlin, Germany. ralf.uebelhack@charite.de
          Article
          S0304-3940(06)00568-4
          10.1016/j.neulet.2006.06.004
          16934400
          06dce33a-fe2f-446e-a126-7c7b5e9c7cd9
          History

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