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      The Determination of Plasma Transferrin Receptor as Good Index of Erythropoietic Activity in Renal Anemia and after Renal Transplantation

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          Abstract

          Both the plasma determinations of erythropoietin (EPO) and transferrin receptor (TfR) would provide a good characterization of anemia especially when mixed erythron disorders underlie, such as in renal failure. Immunologic assays of EPO and TfR, as well as standard hematologic determinations (hematocrit, reticulocyte count, serum iron, transferrin, ferritin) were performed in patients with chronic renal failure (CRF), in regular dialysis treatment (RDT) and in transplanted (TX) patients. In nonanemic TX patients both EPO and TfR ranged normally, whereas in anemic TX ones (Hct < 40%) both values were increased suggesting the physiologic response both of the kidney and of the erythron to decreased red cell mass. In transitory posttransplant erythrocytosis the increased values of TfR, with normal EPO values, would hypothesize a defective feedback to EPO release. Both EPO and TfR values were found increased in TX patients with adult polycystic kidney disease with persistent erythrocytosis (Hct > 50%), thus confirming previous observations. In CRF and RDT patients, all anemic, both EPO and TfR were normal, even though significantly low with respect to the degree of anemia. In RDT seriously anemic patients, the administration of recombinant human EPO induced different patterns of bone marrow response. We conclude that the determination of TfR would provide further information on renal anemia since the receptor increase mostly preceded the rise of Hct, evidencing those patients who will not have an effective bone marrow response to the therapy.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1996
          1996
          18 December 2008
          : 72
          : 4
          : 552-556
          Affiliations
          aDivisione di Nefrologia, Arcispedale S. Anna, bIstituto di Medicina Interna I, e cCattedra di Istologia ed Embriologia, Università di Ferrara, e dLaboratorio Analisi, Arcispedale S. Anna, Ferrara, Italia
          Article
          188938 Nephron 1996;72:552–556
          10.1159/000188938
          8730420
          © 1996 S. Karger AG, Basel

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          Page count
          Pages: 5
          Categories
          Original Paper

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