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A microbe-dependent viral key to Crohn's box.

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Science translational medicine

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      Abstract

      Once Pandora unlocked her fateful box and liberated the evil forces within, it became impossible to put them back. Now, new work on Crohn's disease suggests the existence of a viral "key" that irreversibly renders a genetically susceptible mouse prone to pathogenesis. Indeed, dangerous liaisons among host genotype, viral infection, intestinal injury, and trillions of gut microbes may in part determine which individuals progress to a full-blown disease state. These findings suggest that viral and bacterial triggers may serve as therapeutic targets for Crohn's and prompt new hypotheses that relate inflammation, host immune status, microbial community structure, and human health.

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      Author and article information

      Affiliations
      [1 ] Department of Food Science and Technology, University of Nebraska, Lincoln, NE 68583, USA.
      Journal
      Sci Transl Med
      Science translational medicine
      1946-6242
      1946-6234
      Aug 4 2010
      : 2
      : 43
      20686177
      2/43/43ps39
      10.1126/scitranslmed.3001422

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