ScienceOpen:
research and publishing network
For Publishers
Discovery
Metadata
Peer review
Hosting
Publishing
For Researchers
Join
Publish
Review
Collect
My ScienceOpen
Sign in
Register
Dashboard
Blog
About
Search
Advanced search
My ScienceOpen
Sign in
Register
Dashboard
Search
Search
Advanced search
For Publishers
Discovery
Metadata
Peer review
Hosting
Publishing
For Researchers
Join
Publish
Review
Collect
Blog
About
63
views
0
references
Top references
cited by
271
Cite as...
0 reviews
Review
0
comments
Comment
0
recommends
+1
Recommend
0
collections
Add to
0
shares
Share
Twitter
Sina Weibo
Facebook
Email
3,382
similar
All similar
Record
: found
Abstract
: not found
Article
: not found
HIV infection: epidemiology, pathogenesis, treatment, and prevention
Author(s):
Gary Maartens
,
Connie Celum
,
Sharon R Lewin
Publication date
Created:
July 2014
Publication date
(Print):
July 2014
Journal:
The Lancet
Publisher:
Elsevier BV
Read this article at
ScienceOpen
Publisher
PubMed
Review
Review article
Invite someone to review
Bookmark
Cite as...
There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.
Abstract
HIV prevalence is increasing worldwide because people on antiretroviral therapy are living longer, although new infections decreased from 3.3 million in 2002, to 2.3 million in 2012. Global AIDS-related deaths peaked at 2.3 million in 2005, and decreased to 1.6 million by 2012. An estimated 9.7 million people in low-income and middle-income countries had started antiretroviral therapy by 2012. New insights into the mechanisms of latent infection and the importance of reservoirs of infection might eventually lead to a cure. The role of immune activation in the pathogenesis of non-AIDS clinical events (major causes of morbidity and mortality in people on antiretroviral therapy) is receiving increased recognition. Breakthroughs in the prevention of HIV important to public health include male medical circumcision, antiretrovirals to prevent mother-to-child transmission, antiretroviral therapy in people with HIV to prevent transmission, and antiretrovirals for pre-exposure prophylaxis. Research into other prevention interventions, notably vaccines and vaginal microbicides, is in progress. Copyright © 2014 Elsevier Ltd. All rights reserved.
Related collections
Decoding Infection and Transmission
Author and article information
Journal
Title:
The Lancet
Abbreviated Title:
The Lancet
Publisher:
Elsevier BV
ISSN (Print):
01406736
Publication date Created:
July 2014
Publication date (Print):
July 2014
Volume
: 384
Issue
: 9939
Pages
: 258-271
Article
DOI:
10.1016/S0140-6736(14)60164-1
PubMed ID:
24907868
SO-VID:
06f3fcd5-7993-4908-90ae-69a4bf7ad746
Copyright ©
© 2014
License:
https://www.elsevier.com/tdm/userlicense/1.0/
History
Data availability:
Comments
Comment on this article
Sign in to comment
scite_
Similar content
3,382
Genetics and pathogenesis of idiopathic scoliosis
Authors:
A Grauers
,
E Einarsdottír
,
P Gerdhem
The pathogenesis of adolescent idiopathic scoliosis: review of the literature.
Authors:
Jan-Willem Kouwenhoven
,
René Castelein
Gardnerella and Prevotella : Co-conspirators in the Pathogenesis of Bacterial Vaginosis
Authors:
Tara M. Randis
,
Adam Ratner
See all similar
Cited by
265
HIV Infection and AIDS in Sub-Saharan Africa: Current Status, Challenges and Opportunities
Authors:
Ayesha B.M. Kharsany
,
Quarraisha Karim
The CRISPR/Cas9 system inactivates latent HIV-1 proviral DNA
Authors:
Weijun Zhu
,
Rongyue Lei
,
Yann Le Duff
…
Autophagy-Virus Interplay: From Cell Biology to Human Disease
Authors:
Liyana Ahmad
,
Serge Mostowy
,
Vanessa Sancho-Shimizu
See all cited by
Version 1
- Current
Version 1