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      Biogenic selenium nanoparticles: current status and future prospects.

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          Abstract

          Selenium nanoparticles (SeNPs) are gaining importance in the field of medicine owing to their antibacterial and anticancer properties. SeNPs are biocompatible and non-toxic compared to the counterparts, selenite (SeO3 (-2)) and selenate (SeO4 (-2)). They can be synthesized by physical, chemical, and biological methods and have distinct bright orange-red color. Biogenic SeNPs are stable and do not aggregate owing to natural coating of the biomolecules. Various hypotheses have been proposed to describe the mechanism of microbial synthesis of SeNPs. It is primarily a two-step reduction process from SeO4 (-2) to SeO3 (-2) to insoluble elemental selenium (Se(0)) catalyzed by selenate and selenite reductases. Phenazine-1-carboxylic acid and glutathione are involved in selenite reduction. Se factor A (SefA) and metalloid reductase Rar A present on the surface of SeNPs confer stability to the nanoparticles. SeNPs act as potent chemopreventive and chemotherapeutic agents. Conjugation with antibiotics enhances their anticancer efficacy. These also have applications in nanobiosensors and environmental remediation.

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          Author and article information

          Journal
          Appl. Microbiol. Biotechnol.
          Applied microbiology and biotechnology
          1432-0614
          0175-7598
          Mar 2016
          : 100
          : 6
          Affiliations
          [1 ] Department of Microbiology, Savitribai Phule Pune University, Pune, Maharashtra, 411007, India.
          [2 ] Department of Biochemistry, The Institute of Science, Mumbai, Maharashtra, 400032, India.
          [3 ] Department of Microbiology, Savitribai Phule Pune University, Pune, Maharashtra, 411007, India. bachopade@gmail.com.
          [4 ] Dr. Babasaheb Ambedkar Marathwada University, Aurangabad, Maharashtra, 431004, India. bachopade@gmail.com.
          Article
          10.1007/s00253-016-7300-7
          10.1007/s00253-016-7300-7
          26801915
          0712ef9c-1fe7-47fb-a00b-995c83d0a15a
          History

          Antibacterial activity,Anticancer,Mechanism,Selenate reduction,Selenium nanoparticles

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