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      Management of the failing Fontan circulation

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      Fontan, congenital heart disease, single ventricle, atrial tachycardia, arrhythmia surgery

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          The ‘Fontan circulation' has evolved to include a variety of surgical procedures designed to overcome the absence of two distinct ventricular chambers.1 w1–w3 Inherent to this circulation is chronic elevation of right atrial and vena caval pressure, and absence of a dedicated power source to serve the pulmonary circulation, making low pulmonary vascular resistance and optimal systemic ventricular function the essential ingredients of a successful Fontan circulation.2 Originally designed for the single left ventricle, modifications to the original atriopulmonary connections extended repairs to complex ventricular anatomy, and are now most commonly performed for single right ventricular anatomy associated with hypoplastic left heart syndrome. Together with improved perioperative management, creation of the Fontan circulation in two stages (superior cavopulmonary anastomosis followed by later Fontan completionw4), and performance of Fontan procedures at a younger age, have led to reduced operative mortality associated with the Fontan procedure of ≤5% (compared with 15–30% in earlier decades); survival at 20 years is presently 85%.3 w5 Over the last two decades, the initial survivors of the atriopulmonary Fontan repairs have reached adulthood, bringing a multiplicity of haemodynamic complications and sequelae of their abnormal circulatory status. The atriopulmonary connection is now obsolete as a surgical option, and the current surviving adults with this circulation do not reflect contemporary Fontan outcomes. Nonetheless, their attendant compendium of complications and sequelae provides a daunting array of management challenges, and stigmatises the current perception of long term Fontan outcomes. The ‘Fontan circulation’ now encompasses a spectrum of anatomic substrates, staging options, and operative techniques. Problems classified as ‘Fontan failure’ may represent problems inherent to the morphologic substrate, operative variables, and inevitable sequelae of the Fontan circulation: chronic venous congestion and progressively declining functional status. This review will separate complications into those where intervention may optimise clinical status while maintaining the Fontan circulation—the ‘failing Fontan’—and those conditions which have progressed to a ‘failed Fontan’, where options are limited to cardiac transplantation or attempts to minimise the impact of irreversible functional deterioration. Finally, we will discuss strategies which may alter the incidence and time course of Fontan failure. The failing Fontan circulation Evaluation of the failing or failed Fontan circulation requires knowledge of the anatomic substrate, surgical intervention details, cardiac imaging and assessment of haemodynamic status, assessment of rhythm status, and evaluation of other organ systems and metabolic function. Late Fontan failure may present insidiously over years. It is a failure of medical management to interpret the absence of overt symptoms or ascites as evidence of optimal haemodynamic status in the functionally univentricular circulation. In contrast to other forms of operated congenital heart disease, Fontan patients have lived with less than ideal cardiac output their entire lives, and may neither recognise nor show overt manifestations of progressive decline in functional status until deterioration is quite advanced (table 1). Table 1 Failing Fontan circulation Constitutional Growth failure Inadequate cardiac output Exercise intolerance Chronotropic incompetence, pronounced atrial distension Depression Secondary to limitations on functional status Haemodynamic Obstruction Systemic venous Systemic outflow Atriopulmonary, pulmonary arterial Pulmonary venous return, atrioventricular (AV) valve inflow Ventricular outflow, aortic arch AV valve function ≥Moderate regurgitation ≥Mild stenosis Ventricular dysfunction Secondary: atrial dilatation/distortion; AV valve or semilunar valve dysfunction, chronic arrhythmias or antiarrhythmic medications; impaired myocardial perfusion due to coronary sinus hypertension Thrombosis Systemic venous, atrial, pulmonary Rhythm Arrhythmias Sinus node dysfunction, predominant junctional rhythm, AV block, supraventricular tachycardia/atrial tachycardia, ventricular tachycardia Pulmonary Cyanosis Intracardiac right to left shunt, veno-venous collaterals, pulmonary arteriovenous malformations (AVMs) Pleural effusions Gastrointestinal Ascites Secondary to portal hypertension related to obstruction, versus cirrhosis Metabolic Metabolic markers Declining albumin; thrombocytopenia; hyperbilirubinaemia; coagulopathy Growth In general, the Fontan patient population is shorter in height than the normal population; there is increased recognition that failure to gain weight appropriately is an early indicator of suboptimal cardiac output in childhood.4 Growth failure should prompt a thorough investigation of haemodynamic status, with early efforts to optimise haemodynamic status with catheter or surgical intervention for residual obstruction or valve abnormalities. Exercise capacity is lower in Fontan patients than in other patients with repaired congenital heart disease, and recent studies have reported a 1–3% annual decline in maximal oxygen consumption beginning in adolescence.5 w6–w8 In Fontan patients, the average peak oxygen consumption ranges from 19–28 ml/kg/min, or 50–60% of predicted consumption for age. Decline in exercise function correlates with the need for hospitalisation and symptom development.6 w8 Decreased exercise tolerance is more common in single right or indeterminant ventricular morphology, and in patients with lateral tunnel repairs, and may be related to chronotropic incompetence or abnormal pulmonary compliance with exertion.6 w8 w9 Serial exercise testing may objectively identify changes in haemodynamic or rhythm status, which may be addressed with intervention such as pulmonary stenting, atrial pacing, pulmonary vasodilator therapy, or Fontan conversion surgery.5 Cyanosis A mild degree of desaturation is present in most Fontan patients, due to coronary sinus drainage to the left atrium or pulmonary shunting. Resting saturations <90% suggest the presence of right to left shunting (either intracardiac or due to veno-veno collateral flow to the left atrium) or pulmonary arteriovenous fistulae. Coil embolisation of collaterals or catheter based occlusion of atrial septal defects may improve saturations, although investigation for a more compelling cause for the development of collaterals may allow more definitive intervention. Patients with discontinuous pulmonary arteries with a classic Glenn to the right pulmonary artery have insufficient hepatic flow to that lung, and would benefit from surgical intervention to provide confluent pulmonary arteries and increased hepatic flow to the right lung. Patients with atriopulmonary connections frequently have ‘decompressing’ collateral flow or atrial level shunts, and benefit from Fontan conversion. Pathway obstructions and valve dysfunction The development of haemodynamic abnormalities may be gradual and insidious in Fontan patients, and detection is complicated by the lack of complaints from most patients until pronounced limitation occurs. Decline in exercise tolerance, resting or exercise desaturation, the presence of a murmur, hepatomegaly, or cardiomegaly on radiography are indicators of haemodynamic abnormalities. Patients with atriopulmonary connections develop marked right atrial distension over time, secondary to anatomic obstructions at the anastomosis, or due to the notable energy loss associated with sluggish flow (figure 1). Decompression of the atrium occurs via coronary sinus dilatation, and atrial communications or veno-veno collaterals from the systemic veins to the left atrium or pulmonary veins may ensue. Distension of the right atrium may result in torsion and narrowing of the connection to the pulmonary arteries, as well as compression of the pulmonary venous return from the right lung; the dilated atrium may impinge on inflow in the setting of a right-sided atrioventricular valve. Anatomic obstructions may exist at the atriopulmonary anastomosis or the branch pulmonary arteries; a gradient of >1 mm Hg in this circuit dependent on passive flow is haemodynamically significant. Patients with valved conduits in place, either atrioventricular or atriopulmonary, invariably develop obstruction over time. Patients with lateral tunnel repairs in general do not develop pronounced atrial distension, but narrowing at the pulmonary arteries may exist. Abnormalities of atrioventricular (AV) valve function result in elevated left atrial pressure, which will harm the pulmonary circulation. Chronic aortic outflow obstruction will result in hypertrophy and diminished ventricular compliance; the volume overload of aortic insufficiency will contribute to ventricular failure. Figure 1 MRI of marked atrial dilatation with impingement on pulmonary venous return in a patient with an atriopulmonary Fontan anastomosis for tricuspid atresia. Right atrium measures 7×7.5 cm. Image courtesy of Cynthia K Rigsby, Children's Memorial Hospital, Chicago, Illinois, USA. Hepatic and infra-diaphragmatic venous congestion is present in all Fontan patients, to greater or lesser degrees. Sequestration of platelets by the liver and spleen result in thrombocytopenia, present in 15–25% of adult Fontan patients. Mild elevation of bilirubin is common, followed by abnormalities of liver enzymes. The effects of years of venous congestion will result in hepatic cirrhosis, which becomes apparent by approximately 11 years following surgery.7 Surveillance with abdominal ultrasound may detect hepatic nodules, with more detailed imaging provided by CT. Monitoring of α-fetoprotein may provide early detection of hepatocellular carcinoma, now reported in a small number of older Fontan patients. Arrhythmias This broad term includes sinus node dysfunction, predominant junctional rhythm, atrioventricular block, supraventricular and ventricular arrhythmias, and the risk of arrhythmic sudden death. Modifications to the Fontan procedure have resulted in a decreased incidence of sinus node dysfunction and atrial arrhythmias. Sinus node dysfunction is reported in 40% of patients with atriopulmonary connections, and is reported in up to 25% of lateral tunnel and extracardiac cavopulmonary connection surgeries.8 9 w10 w11 Reassurance based on an ‘adequate overall heart rate’, which is usually junctional, is a disservice to the patient, as the haemodynamic consequences of junctional rhythm in the Fontan circulation are profound, including acute elevation of atrial pressure with each ventricular contraction. Non-sinus rhythm has been associated with increased risk of atrial arrhythmias, as well as an increased risk of hepatic fibrosisw12; these data warrant vigorous attempts to maintain regular atrial rhythm in Fontan patients. The incidence of atrial arrhythmias during long term follow-up has decreased with surgical modifications of the Fontan procedure, from as many as 60% of atriopulmonary patients to approximately 12% of extracardiac total cavopulmonary connection patients.9–13 w5 w13 Atrial reentrant tachycardia accounts for approximately 75% of supraventricular tachycardia, with focal atrial tachycardia in up to 15% of patients.w13 w14 In lateral tunnel patients, the reentrant circuit may reside in the pulmonary venous atrium. Atrial fibrillation is becoming increasingly common in adult Fontan patients, and is present in almost half of patients referred for Fontan conversion. Risk factors for the development of atrial tachycardia include an atriopulmonary connection, preoperative bradycardia, lack of sinus rhythm, older age at Fontan and longer postoperative interval, greater than mild atrioventricular valve regurgitation, and heterotaxy syndrome.3 9 11 w11 As the incidence of atrial tachycardia increases with the postoperative interval and is a major source of morbidity,8 10 regular surveillance of rhythm with ambulatory 24 h monitors, event monitors and exercise testing becomes more important during long term follow-up. Termination of an acute episode of atrial tachycardia within 24–48 h from onset is recommended whenever possible, due to the rapid deterioration in haemodynamic status associated with tachycardia in the single ventricle circulation. Figure 2 summarises an algorithm for management of atrial arrhythmias.w15 Development of atrial tachycardia is commonly associated with haemodynamic abnormalities which will require more extensive haemodynamic, functional, and metabolic evaluation. Catheter ablation for atrial tachycardia in Fontan patients has considerably lower success rates than in other forms of repaired congenital heart disease. Acute success rates from catheter ablation in the Fontan patient range from 40–75%, with recurrence of tachycardia in 60% of patients during the first year.14 w14 Catheter ablation in this population is best suited for patients with lateral tunnel repairs and focal atrial tachycardia, or atriopulmonary repairs who are not suitable candidates for Fontan arrhythmia surgery. The development of significant arrhythmias in the atriopulmonary or atrioventricular Fontan modification, when coupled with signs of heart failure, is associated with a 3 year mortality rate of 25%.6 Figure 2 Management of atrial arrhythmias in Fontan patients. PLE, protein-losing enteropathy. Fontan conversion with arrhythmia surgery Recognition that atriopulmonary Fontan patients have associated haemodynamic limitations in addition to atrial tachycardia led our group to incorporate arrhythmia surgery into Fontan conversion to an extracardiac total cavopulmonary connection, beginning in 1994.15 w16 In addition to right atrial reduction, performance of a modified right atrial maze procedure eliminates right atrial macro-reentrant tachycardia, but is not intended to treat focal atrial tachycardia or other mechanisms without targeted resection (figure 3). Left atrial macro-reentrant tachycardia or atrial fibrillation is treated with an additional left atrial Cox Maze III, which effectively eliminates atrial fibrillation, but we have noted recurrence of a slower organised atrial reentry tachycardia in about 15% of such patients.w16 Implantation of epicardial dual chamber anti-tachycardia pacing systems is performed for virtually all patients, predominantly relying on atrial pacing at rates of 70–80 beats/min chronically, without ventricular pacing. Our centre has performed over 135 Fontan conversions with arrhythmia surgery at a mean interval of 15.5±5.2 years following initial Fontan procedure, with acute mortality of 1.5%; other centres have achieved relatively comparable results.16 Analysis of intermediate outcomes in the initial 110 patients undergoing such surgery at our centre showed freedom from death or transplantation at 15 years of follow-up was 80%, with freedom from recurrent tachycardia of 85%. Risk factors for poor outcomes in this population include right or ambiguous ventricle, presence of right atrial thrombus at time of surgery, older age at Fontan conversion, longer post-Fontan interval, or ascites. Patients with protein-losing enteropathy are not considered candidates for Fontan conversion surgery, and patients without correctable causes of poor ventricular function, or multiorgan system disease, may be better treated by transplantation. We have recently demonstrated improved functional status at 5 years of follow-up in a subset of patients undergoing paired pre- and post-Fontan conversion exercise testing, with an average 17% increase in maximal oxygen consumption. These results suggest that aggressive efforts to improve flow dynamics and associated haemodynamic abnormalities, eliminate arrhythmias, and maintain chronic atrial rhythm may favourably alter what has been considered as an ‘inexorable decline’ in functional status in many Fontan patients. Figure 3 Surgical modifications of atrial maze procedure in complex anatomy. Solid black lines indicate sites of cryoablation. avn, atrioventricular node; CS, coronary sinus; FO, foramen ovale; HV, hepatic vein; IVC, inferior vena cava; LAA, left atrial appendage; LSVC, left superior vena cava; MV, mitral valve; PV, pulmonic vein; RAA, right atrial appendage; RSVC, right superior vena cava; TAPVR, total anomalous pulmonary venous return; TV, tricuspid valve. Reprinted with permission from Mavroudis C, Deal BJ, Backer CL, Tsao S. Arrhythmia surgery in patients with and without congenital heart disease. Ann Thorac Surg 2008;86:857–68. In addition to atrial arrhythmias, atrioventricular block occurs, either due to intrinsic conduction abnormalities as seen in patients with l-transposition, or as a consequence of surgery. The incidence of pacemaker implantation in most series ranges from 3–18%, without stratification as to implantation for AV block versus sinus node dysfunction.3 w5 w17 Limitations of venous access to the atrium, the risk of endocardial lead thrombosis, and the morbidity of repeat sternotomy to place epicardial leads, support a preemptive strategy of atrial lead placement at the time of primary Fontan repair, although not a class I or II indication for pacing by current recommendations. With improved survival, it is becoming apparent that ventricular arrhythmias are noted in 3–12% of adult patients.17 w5 w17 The contribution of ventricular arrhythmias to late sudden death, reported in 9% of patients, is not yet known.18 Ascites Ascites may develop as a consequence of elevated right atrial pressure, protein-losing enteropathy or hepatic dysfunction, and requires clarification of the aetiology with aggressive evaluation and treatment. Ascites may occur without hypoalbuminaemia, but is an advanced indicator of a failing Fontan circulation; in this setting, Fontan conversion with arrhythmia surgery may be feasible, although with increased risk of later Fontan failure. A small number of patients have persistent or recurrent ascites late after Fontan conversion, without evidence of Fontan circulation obstruction. In this setting, ascites is thought to be related to hepatic dysfunction. Diuretic therapy and optimisation of medical therapy may minimise ascites; regular evaluation of cirrhotic changes with abdominal ultrasound, CT or MRI, and monitoring of liver function, is recommended. When advanced cardiac liver cirrhosis changes are noted, the risk for hepatocellular carcinoma increases.7 Combined cardiac and liver transplantation for a Fontan patient has been performed successfully.w18 The failed Fontan In the unusual setting of early postoperative failure, a failed circulation requires early takedown of the Fontan surgical circuit. Late failure, discussed here, includes haemodynamic or multiorgan system complications of the Fontan circulation which are not reversible by surgical or catheter interventions at acceptable risk. Strategies to minimise/palliate complications or consideration for cardiac transplantation are the limited therapeutic options. Table 2 summarises the conditions associated with a failed Fontan, which are discussed in several excellent reviews.19 w19 Most studies report early operative mortality for Fontan patients undergoing cardiac transplantation at approximately 30%, higher than that reported for other forms of congenital heart disease,20 although one recent study showed no difference in early mortality among Fontan patients.w20 Problems specific to the Fontan patient undergoing transplantation include multiple prior surgeries with increased sensitisation rates between 20–60%, with preformed antibodies to donor human leucocyte antigens (HLA), complexities of venous anatomy, malnourishment associated with protein-losing enteropathy, and acute graft right heart failure. After the early transplant period, there is no difference in long term survival compared with other forms of congenital heart disease, with survival rates at 10 years of around 54%.w21 w22 Due to the significant mortality on the waiting list and elevated early mortality, there is interest in developing implantable mechanical assist devices in Fontan patients as either a bridge to transplantation, or ‘destination therapy’.w23 w24 Table 2 Failed Fontan circulation Condition Incidence Manifestations Aetiologies Treatments Early failure 3% Low cardiac output, pleural effusions, chylothoraces, ascites, hepatomegaly Pulmonary vasculature abnormalities Incessant/refractory atrial tachycardia Residual obstruction related to surgical technique Early evaluation to correct obstructions, terminate tachycardia Fontan takedown Recreate systemic to pulmonary blood flow Cardiac transplantation Late failure Lymphatic dysfunction Protein-losing enteropathy (PLE) 2–13% Ascites, peripheral oedema, pleural effusions, diarrhoea, malabsorption of fat, hypoalbuminaemia Unknown, but associated with: Low cardiac output Mesenteric vascular flow abnormalities Intestinal cellular wall damage Autoimmune reactions Intestinal lymphangiectasia Risk factors: prolonged postoperative chest tube drainage, systemic right ventricle Nutritional support with protein and medium chain triglycerides Optimise cardiac output: atrial rhythm, pulmonary vasodilator therapy, afterload reduction, atrial fenestration Enteric steroids Diuretics Heparin High dose aldactone Intravenous albumin and γ-globulin infusions Immunosuppression Cardiac transplantation Plastic bronchitis <2% Tachypnoea, cough, wheezing, expectoration of bronchial casts Unknown; associated with leakage of proteinaceous material into the airways resulting in bronchial casts Urgent bronchial lavagePulmonary vasodilatorsCardiac transplantation Primary ventricular dysfunction ∼7–10% Progressive exercise intolerance, AV valve insufficiency, hepatomegaly, ascites Chronic hypertrophy, abnormal ventricular morphology (systemic right or indeterminate ventricle), older age at repair, prolonged cyanosis or volume overload, myocardial perfusion abnormalities ACE inhibition Pulmonary vasodilators Calcium channel blockers for diastolic dysfunction β-blockers Multisite pacing Cardiac transplantation Progressive increase in pulmonary resistance Unknown Hypoxaemia Pulmonary arteriovenous malformations, inadequate hepatic vein effluent, lack of pulsatile flow Pulmonary vasodilators; stenting of pulmonary arterial narrowing Hepato-renal insufficiency Low cardiac output, sepsis Supportive care, optimise cardiac output, high mortality Hepatic failure Unknown Hepatomegaly, ascites; hepatocellular carcinoma Progression of chronic cardiac cirrhosis Cardiac and liver transplantation Failure of medical care At this stage in our knowledge of the natural history of the Fontan circulation, several concepts have become clear, including: (1) the unique challenges of the functionally univentricular circulation with progressive multiorgan system impact; (2) the inability to definitively treat a truly ‘failed’ Fontan with measures other than cardiac transplantation; (3) the inadequacy of traditional cardiac follow-up visits to reliably detect subtle changes in circulation before advanced stages; and (4) the challenges in ‘cardiac’ management that present unlike any other repaired congenital cardiac anomalies. In addition, the collective memory of the earlier high mortality or prolonged hospital courses associated with primary Fontan surgery in past decades has made many clinicians reluctant to recommend additional interventions, particularly without overt symptoms. In addition to standard haemodynamic evaluations, more global assessment of the impact of the Fontan physiology on other organ systems needs to become part of routine surveillance (table 2). It cannot be assumed that the patient has other healthcare providers with adequate knowledge of the impact of the Fontan circulation to monitor these systems. Growth failure in childhood and weight loss in adulthood are advanced manifestations of inadequate haemodynamic status. In adulthood, exercise intolerance may result in extremes of a sedentary lifestyle and result in obesity. By contributing to alterations in pulmonary functionw22 and increased systemic vascular resistance, overweight contributes rapidly to Fontan failure. Patients should be counselled on the importance of regular aerobic activity for conditioning, and avoidance of overweight as essential to limiting Fontan failure. In the USA, the cardiologist caring for Fontan patients is now asked to routinely monitor and assess other organ systems, including haematologic, endocrine, pulmonary, hepatic and gastrointestinal, within the confines of decreased reimbursement for testing and shorter office visits. The barriers to sophisticated medical care for the older Fontan patient encompass difficulties in education of the patient relative to the need for regular cardiac care, availability of comprehensive integrated care centres with sufficient expertise, and in many countries the lack of healthcare coverage. Nonetheless, it is apparent that a change in practice for the routine long term follow-up of Fontan patients is necessary in order to detect progressive subtle decline in status and to have a favourable impact on the functional status of these unique survivors (table 3). Failure to change our standard methods of routine cardiac care in this setting constitutes a failure of optimal medical management. Chronic pulmonary vasodilator therapy, in addition to chronic diuresis, may become part of routine long term medical therapy as this population ages.w25 Better strategies for improving vascular endothelial function and liver protection, including the usage of polyphenols and thiazolidinediones, will become areas for future studies.w26 Table 3 Long term Fontan surveillance Parameters Monitoring Constitutional Adequate growth in childhood Weight or muscle loss in adulthood Avoid overweight Blood pressure: normotensive Functional classification, Aerobic activity Daily napping Aerobic activity Exercise testing Cardiac haemodynamics Heart size Atrial dilatation Atriopulmonary anastomosis Pulmonary narrowing, distortion Pulmonary venous or atrioventricular (AV) inflow obstruction AV valve regurgitation or stenosis Aortic insufficiency Ventricular outflow obstruction Arch obstruction Ventricular function Echocardiogram Periodic chest radiograph Cardiac MRI or CT Rhythm Presence of atrial versus junctional rhythm Resting heart rate Chronotropic response to exertion Arrhythmia development Periodic 24 h ambulatory monitoring; event monitoring Pulmonary HypoxaemiaVascular resistance Oxygen saturation, resting and exertional Endocrine Thyroid function Thyroid stimulating hormone (TSH), thyroxine (T4) Renal Blood urea nitrogen, creatinine Hepatic Hepatomegaly Cardiac cirrhosis Synthetic function Liver function: enzymes, coagulation Abdominal ultrasound, CT or MR Liver biopsy Serum α-fetoprotein Gastrointestinal Bloating, distension, diarrhoea, ascites, gallstones Stool α-1 anti-trypsin Haematologic Anaemia, polycythaemia, thrombocytopenia Blood count, platelets Metabolic B-type natriuretic peptide, albumin, alkaline phosphatase Neurologic Cerebrovascular accident Depression Management of the failing Fontan circulation: key points Symptoms develop at an advanced stage of declining Fontan circulation. Identification of the ‘failing’ Fontan before the development of ascites or protein-losing enteropathy is essential to improve outcomes. Monitoring functional status, rhythm, serum biomarkers, and liver changes is essential to long term assessment of ‘cardiac’ status. Ablation procedures for atriopulmonary Fontan patients have a low likelihood of success. Aggressive therapy for rhythm and haemodynamic abnormalities may improve long term functional status. You can get CPD/CME credits for Education in Heart Education in Heart articles are accredited by both the UK Royal College of Physicians (London) and the European Board for Accreditation in Cardiology—you need to answer the accompanying multiple choice questions (MCQs). To access the questions, click on BMJ Learning: Take this module on BMJ Learning from the content box at the top right and bottom left of the online article. For more information please go to: http://heart.bmj.com/misc/education.dtl RCP credits: Log your activity in your CPD diary online (http://www.rcplondon.ac.uk/members/CPDdiary/index.asp)—pass mark is 80%. EBAC credits: Print out and retain the BMJ Learning certificate once you have completed the MCQs—pass mark is 60%. EBAC/ EACCME Credits can now be converted to AMA PRA Category 1 CME Credits and are recognised by all National Accreditation Authorities in Europe (http://www.ebac-cme.org/newsite/?hit=men02). Please note: The MCQs are hosted on BMJ Learning—the best available learning website for medical professionals from the BMJ Group. If prompted, subscribers must sign into Heart with their journal's username and password. All users must also complete a one-time registration on BMJ Learning and subsequently log in (with a BMJ Learning username and password) on every visit. Supplementary Material Supporting Statement Supporting Statement

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          Predictors of morbidity and mortality in contemporary Fontan patients: results from a multicenter study including cardiopulmonary exercise testing in 321 patients.

          previous studies have established an association between exercise intolerance and increased morbidity and mortality in congenital heart disease patients. We aimed to clarify if exercise intolerance is associated with poor outcome in Fontan patients and to identify risk factors for mortality, transplantation, and cardiac-related hospitalization. a total of 321 Fontan patients (57% male, mean age 20.9 ± 8.6 years) who underwent cardiopulmonary exercise testing (CPET) at four major European centres between 1997 and 2008 were included. During a median follow-up of 21 months, 22 patients died and 6 patients underwent cardiac transplantation (8.7%), resulting in an estimated 5-year transplant-free survival of 86%. Parameters of CPET were strongly related to increased risk of hospitalization, but-with the exception of heart rate reserve-unrelated to risk of death or transplantation. In contrast, patients with clinically relevant arrhythmia had a 6.0-fold increased risk of death or transplantation (P < 0.001). Furthermore, patients with atriopulmonary/-ventricular Fontan had a 3.7-fold increased risk of death or transplantation compared with total cavopulmonary connection patients (P= 0.009). The combination of clinically relevant arrhythmia, atriopulmonary/-ventricular Fontan, and signs of symptomatic or decompensated heart failure was associated with a particularly poor outcome (3-year mortality 25%). on short-term follow-up, most parameters of CPET are associated with increased risk of hospitalization but not death or transplantation in contemporary Fontan patients. Only decreased heart rate reserve and a history of clinically relevant arrhythmia, atriopulmonary/-ventricular Fontan, and/or heart failure requiring diuretic therapy are associated with poor prognosis, potentially identifying patients requiring medical and/or surgical attention.
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            The Fontan procedure: contemporary techniques have improved long-term outcomes.

            To determine whether patients undergoing the lateral tunnel and extracardiac conduit modifications of the Fontan procedure have better outcomes than patients undergoing a classical atriopulmonary connection. Between 1980 and 2000, 305 consecutive patients underwent a Fontan procedure at our institution. There were 10 hospital deaths (mortality: 3%) with no death after 1990. Independent risk factors for mortality were preoperative elevated pulmonary artery pressures (P=0.002) and common atrioventricular valve (P=0.04). Fontan was taken down during hospital stay in 7 patients. A mean of 12+/-6 years of follow-up was obtained in the 257 nonforeign Fontan survivors. Completeness of concurrent follow-up was 96%. Twenty-year survival was 84% (95% CI: 79 to 89%). Recent techniques improved late survival. The 15-year survival after atriopulmonary connection was 81% (95% CI: 73% to 87%) versus 94% (95% CI: 79% to 98%) for lateral tunnel (P=0.004). Nine pts required heart transplantation (8 atriopulmonary connection, 1 lateral tunnel). Undergoing a Fontan modification independently predicted decreased occurrence of arrhythmia, and 15-year freedom from SVT was 61% (95% CI: 51% to 70%) for atriopulmonary connection versus 87% (95% CI: 76% to 93%) for lateral tunnel (P=0.02). Freedom from Fontan failure (death, take-down, transplantation, or NYHA class III-IV) was 70% (95% CI: 58% to 79%) at 20 years. After extra-cardiac conduits, no death, SVT, or failure was observed. The Fontan procedure remains a palliation, but outcomes of patients have improved. Better patient selection minimizes hospital mortality. Patients with lateral tunnel and extracardiac conduit modifications experience less arrhythmia and are likely to have failure of their Fontan circulation postponed.
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              Outcome of listing for cardiac transplantation for failed Fontan: a multi-institutional study.

              The Fontan procedure is a successful palliation for children with single-ventricle physiology; however, many will eventually require heart transplantation. The purpose of this study was to determine risk factors for death awaiting transplantation and to examine results after transplantation in Fontan patients. A retrospective, multi-institutional review was performed of 97 Fontan patients 30 days after transplantation. Heart transplantation is an effective therapy for pediatric patients with a failed Fontan. Although early posttransplantation survival is slightly lower than other patients with CHD, long-term results are encouraging, and protein-losing enteropathy can be expected to resolve.

                Author and article information

                BMJ Group (BMA House, Tavistock Square, London, WC1H 9JR )
                15 July 2012
                15 July 2012
                : 98
                : 14
                : 1098-1104
                [1 ]Division of Cardiology, Children's Memorial Hospital, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
                [2 ]Department of Pediatric and Congenital Heart Surgery, Center for Pediatric and Congenital Heart Disease, Cleveland Clinic Foundation, Cleveland, Ohio, USA
                Author notes
                Correspondence to Dr Barbara J Deal, Division of Cardiology, Children's Memorial Hospital, 2300 Children's Plaza, mc 21, Chicago, IL 60614, USA; bdeal@ 123456childrensmemorial.org
                © 2012, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

                This is an open-access article distributed under the terms of the Creative Commons Attribution Non-commercial License, which permits use, distribution, and reproduction in any medium, provided the original work is properly cited, the use is non commercial and is otherwise in compliance with the license. See: http://creativecommons.org/licenses/by-nc/2.0/ and http://creativecommons.org/licenses/by-nc/2.0/legalcode.

                Education in Heart
                Congenital heart disease

                Cardiovascular Medicine
                arrhythmia surgery,atrial tachycardia,fontan,congenital heart disease,single ventricle


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