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      Clinical Value of 99Tc m-MDP SPECT Bone Scintigraphy in the Diagnosis of Unilateral Condylar Hyperplasia

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      The Scientific World Journal
      Hindawi Publishing Corporation

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          Abstract

          Purpose. To investigate the clinical value of 99Tc m-MDP SPECT for the diagnosis of unilateral condylar hyperplasia (UCH). Methods. One hundred forty-nine patients who underwent mandibular 99Tc m-MDP SPECT between January 2009 and December 2012 were studied, including 105 cases that were clinically suspected of UCH and 44 comparable cases without UCH as a control group. Results. Increased bone activity was observed in the affected condyles for all UCH patients. In the UCH group, the relative percentage uptake on the affected side was 59% (SD ± 4.3%), significantly higher than the 41% (SD ± 4.1%) uptake on the contralateral side (P<0.001). Similarly, the condyle/skull ratio was significantly higher for the affected side (1.66 ± 0.63) than for the contralateral side (1.34 ± 0.34, P < 0.01. No significant difference was found in the control group between the left and right condyles. Values for the sensitivity (95%), specificity (61%), positive (84.4%) and negative (84.6%) predictive values, and accuracy (84.5%) for 99Tc m-MDP SPECT in the diagnosis of UCH were calculated. However, for the hyperplastic condyle, no correlation was observed between the thickness of each cartilage layer and the relative uptake in the SPECT image. Conclusion. 99Tc m-MDP SPECT is accurate for diagnosing UCH and can provide a reference for treatment options.

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          Hemimandibular hyperplasia--hemimandibular elongation.

          Clinical and radiographic experience as well as histological findings leave no doubt that the term "condylar hyperplasia" refers only to hyperplasia of the condyle alone and should therefore not be used to mean the two hemimandibular anomalies as is the case in the literature today. There are two basically different malformations of one side of the mandible which we call hemimandibular hyperplasia and hemimandibular elongation respectively. We are convinced that there exist pure and mixed forms of both growth anomalies because we have observed several such clinical cases. The stimulus for the abnormal growth either lies within the fibrocartilaginous layer or is produced by it. Different histological patterns within the condylar growth zone were seen in the two anomalies. The pathophysiological bases of the abnormal growth are discussed. They seem to contribute to the understanding of the normal and abnormal mandibular growth and consequently also of many of the mandibular anomalies. The explanations are demonstrated by the illustrations of some cases.
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            The clinical characteristics of condylar hyperplasia: experience with 61 patients.

            Much reported variation and discord exist regarding mandibular condylar hyperplasia (CH). This study evaluated some of the characteristics of this disorder in a series of 61 patients with active CH.
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              Female predominance and effect of gender on unilateral condylar hyperplasia: a review and meta-analysis.

              The objective of this review and meta-analysis was to determine the existence and extent of the predominance of women among patients with unilateral condylar hyperplasia (UCH). Furthermore, we examined the laterality of UCH in women and men from international study populations.
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                Author and article information

                Journal
                ScientificWorldJournal
                ScientificWorldJournal
                TSWJ
                The Scientific World Journal
                Hindawi Publishing Corporation
                2356-6140
                1537-744X
                2014
                11 May 2014
                : 2014
                : 256256
                Affiliations
                Department of Nuclear Medicine, Zhongnan Hospital of Wuhan University, 169 Donghu Road, Wuchang, Wuhan, Hubei 430071, China
                Author notes

                Academic Editor: Alberto Cuocolo

                Article
                10.1155/2014/256256
                4037566
                073d1bfc-9619-4d46-9fc7-02e9669578b9
                Copyright © 2014 Bing Wen et al.

                This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                : 21 February 2014
                : 24 April 2014
                : 24 April 2014
                Categories
                Clinical Study

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