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      Self-Assembled Colloidal Gel Using Cell Membrane-Coated Nanosponges as Building Blocks

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          Abstract

          <p class="first" id="P1">Colloidal gels that combine oppositely charged nanoparticles are increasingly leveraged for drug delivery and tissue engineering applications. Meanwhile, cell membrane-coated nanoparticles are becoming unique biomimetic nanomedicine for innovative therapeutics. Inspired by the remarkable potential of both platforms, herein we investigate the use of cell membrane-coated nanosponges as building blocks to form colloidal gel. Specifically, we prepare red blood cell membrane-coated nanoparticles (namely ‘nanosponges’, denoted ‘RBC-NPs’). In the presence of appropriate cationic nanoparticles, the nanosponges self-assemble to form a gel-like and cohesive complex (namely ‘nanosponge colloidal gel’, denoted ‘NC-gel’). When applied with an external shear force, the NC-gel shows shear-thinning behavior; however, upon removal of the external force, the cohesive property recovers. The NC-gel not only preserves the toxin neutralization capability of the nanosponges, but also prolongs their retention after subcutaneous injection into mouse tissues. In a mouse model of subcutaneous Group A <i>Streptococcus</i> (GAS) infection, the NC-gel shows significant antibacterial efficacy by markedly reducing skin lesion development. Overall, we demonstrate the successful use of cell membrane-coated nanoparticles as building blocks to formulate colloidal gel that entirely based on material self-assembly without chemical cross-linking. The new colloidal gel system is promising as an injectable formulation for therapeutic applications such as antivirulence treatment for local bacterial infections. </p>

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          Author and article information

          Journal
          ACS Nano
          ACS Nano
          American Chemical Society (ACS)
          1936-0851
          1936-086X
          October 04 2016
          December 26 2017
          November 10 2017
          December 26 2017
          : 11
          : 12
          : 11923-11930
          Affiliations
          [1 ]Department of Nanoengineering, ‡Moores Cancer Center, §Department of Pediatrics, ∥Skaggs School of Pharmacy and Pharmaceutical Sciences, ⊥Department of Bioengineering, and #Sanford Consortium for Regenerative Medicine, University of California San Diego, La Jolla, California 92093, United States
          Article
          10.1021/acsnano.7b06968
          6336496
          29116753
          077a5afd-64dc-4016-ae7b-9b701bad2b00
          © 2017
          Product
          Self URI (article page): http://pubs.acs.org/doi/10.1021/acsnano.7b06968

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