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      Mucositis in head and neck cancer patients treated with radiotherapy and systemic therapies: Literature review and consensus statements.

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          Abstract

          Oral mucositis (OM) due to radiotherapy and systemic therapies in head and neck cancer treatment represents a major problem causing a wide spectrum of clinical signs and symptoms. This adverse event may reduce quality of life, resulting from debilitating oral pain, bleeding, dysphagia, infections, impairment of food intake, high rate of hospitalization and may interfere with the delivery of programmed treatment plans, ultimately jeopardizing patient outcome. Globally, there is a lack of evidence on effective measures for the prevention and treatment of OM, and only scant uniform conclusions and recommendations can be derived from the existing literature and guidelines. A multidisciplinary team of Italian head and neck cancer experts met in Milan 17-18 February 2013 with the aim of reaching consensus on prophylaxis and management of mucositis. The results of the literature review and the statements that achieved consensus are reported and discussed in this paper.

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          Author and article information

          Journal
          Crit. Rev. Oncol. Hematol.
          Critical reviews in oncology/hematology
          Elsevier BV
          1879-0461
          1040-8428
          Apr 2016
          : 100
          Affiliations
          [1 ] Department of Radiotherapy, University "La Sapienza", Rome, Italy. Electronic address: vitaliana.desanctis@uniroma1.it.
          [2 ] Head and Neck Medical Oncology Unit, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy. Electronic address: paolo.bossi@istitutotumori.mi.it.
          [3 ] Department of Radiotherapy, National Cancer Institute Regina Elena, Rome, Italy. Electronic address: Gsangui1@gmail.com.
          [4 ] Radiation Oncology Department, A. O. S. Maria, Terni, Italy. Electronic address: fabiotrippa@gmail.com.
          [5 ] Medical Oncology Department, AO. S. Paolo, Milano, Italy. Electronic address: daris.ferrari@ao-sanpaolo.it.
          [6 ] IRCCS San Martino-IST, Largo R Benzi 10, 16132 Genoa, Italy. Electronic address: almalina.bacigalup@hsanmartino.it.
          [7 ] Supportive Care in Cancer Unit, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy. Electronic address: carla.ripamonti@istitutotumori.mi.it.
          [8 ] Radiation Oncology Department, Spedali Civili Hospital, Brescia University, Italy. Electronic address: michela.buglione@unibs.it.
          [9 ] Radiation Oncology Department, Unit of University of Messina, Italy. Electronic address: Stefano.pergolizzi@unime.it.
          [10 ] Department of Radiation Oncology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. Electronic address: j.a.langendijk@umcg.nl.
          [11 ] Division of Hematology/Oncology, Department of Medicine, Vanderbilt University, Nashville, TN, USA. Electronic address: barbara.murphy@vanderbilt.edu.
          [12 ] Department of Oral and Maxillofacial Surgery, Academic Medical Center Amsterdam, University of Amsterdam, Amsterdam, The Netherlands; Department of Medical Dental Interaction, Academic Center for Dentistry Amsterdam, University of Amsterdam and VU University, Amsterdam, The Netherlands. Electronic address: j.e.raberdurlacher@amc.uva.nl.
          [13 ] Radiation Oncology Department, AO. S. Croce e Carle, Cuneo, Italy. Electronic address: elviorussi@gmail.com.
          [14 ] Section of Oral Medicine, MC1605, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030-1605, USA. Electronic address: lalla@uchc.edu.
          Article
          S1040-8428(16)30009-9
          10.1016/j.critrevonc.2016.01.010
          26947812
          077ce6c3-d5e1-47a2-b832-cf0ad8f46097
          History

          Chemoradiation,Chemotherapy,Clinical management,Head and neck cancer,Mucositis,Oral mucositis,Radiation therapy,Radiotherapy,Supportive care

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