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      Process standardization and characterization of Rajata Sindura

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          Abstract

          Background:

          Rajata Sindura (RS) is a mercurial preparation, known for its properties like Rasayana (rejuvinating), Balya (strengthening), Vrushya (aphrodisiac), Medhya (increasing intellect) and can cure various diseases when used with appropriate adjuvant. It is prepared with Hingulottha Parada (purified mercury), Shuddha Gandhaka (purified sulfur) and Shuddha Rajata (purified silver) in a proportion of 1:1:4. Process standardization and characterization of RS are not reported until date.

          Aim:

          Pharmaceutical standardization and characterization of Rajata Sindura.

          Materials and Methods:

          Purified mercury and silver were triturated to form amalgam, followed by the addition of purified sulfur to prepare Kajjali and lavigated with Vatankura (leaf buds of Ficus benghalensis Linn.) swarasa (juice). This Kajjali was processed by Kupipakwa method.

          Results and Conclusion:

          RS was prepared in 33 h with 20.25% yield. Scanning electron microscope coupled with energy dispersive spectroscopy analysis has shown Mercury 86.21%, sulfur 13.27% as major elements; iron, calcium, potassium, magnesium and silver were other detected minor elements. X-ray diffraction report revealed the chemical nature of RS as HgS compound, having cubic crystal structure.

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          Most cited references23

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          In Vivo Effects Of Traditional Ayurvedic Formulations in Drosophila melanogaster Model Relate with Therapeutic Applications

          Background Ayurveda represents the traditional medicine system of India. Since mechanistic details of therapy in terms of current biology are not available in Ayurvedic literature, modern scientific studies are necessary to understand its major concepts and procedures. It is necessary to examine effects of the whole Ayurvedic formulations rather than their “active” components as is done in most current studies. Methods We tested two different categories of formulations, a Rasayana (Amalaki Rasayana or AR, an herbal derivative) and a Bhasma (Rasa-Sindoor or RS, an organo-metallic derivative of mercury), for effects on longevity, development, fecundity, stress-tolerance, and heterogeneous nuclear ribonucleoprotein (hnRNP) levels of Drosophila melanogaster using at least 200 larvae or flies for each assay. Results A 0.5% (weight/volume) supplement of AR or RS affected life-history and other physiological traits in distinct ways. While the size of salivary glands, hnRNP levels in larval tissues, and thermotolerance of larvae/adult flies improved significantly following feeding either of the two formulations, the median life span and starvation resistance improved only with AR. Feeding on AR or RS supplemented food improved fecundity differently. Feeding of larvae and adults with AR increased the fecundity while the same with RS had opposite effect. On the contrary, feeding larvae on normal food and adults on AR supplement had no effect on fecundity but a comparable regime of feeding on RS-supplemented food improved fecundity. RS feeding did not cause heavy metal toxicity. Conclusions The present study with two Ayurvedic formulations reveals formulation-specific effects on several parameters of the fly's life, which seem to generally agree with their recommended human usages in Ayurvedic practices. Thus, Drosophila, with its very rich genetic tools and well-worked-out developmental pathways promises to be a very good model for examining the cellular and molecular bases of the effects of different Ayurvedic formulations.
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            The Ayurvedic Pharmacopoeia of India

            (2006)
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              Preparation and characterization of a mercury based Indian traditional drug Ras-sindoor.

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                Author and article information

                Journal
                Ayu
                Ayu
                AYU
                Ayu
                Medknow Publications & Media Pvt Ltd (India )
                0974-8520
                0976-9382
                Jan-Mar 2014
                : 35
                : 1
                : 63-70
                Affiliations
                [1]Department of Rasa Shastra and Bhaishjya Kalpana, Mahatma Gandhi Ayurved College, Hospital and Research Centre, Wardha, Maharashtra, India
                [1 ]Department of Dravyaguna, Mahatma Gandhi Ayurved College, Hospital and Research Centre, Wardha, Maharashtra, India
                [2 ]Department of Rasa Shastra and Bhaishjya Kalpana, Government Ayurveda Medical College, Bengaluru, Karnataka, India
                Author notes
                Address for correspondence: Dr. Rohit Ajith Gokarn, Department of RS and BK, Mahatma Gandhi Ayurved College, Hospital and Research Centre, Wardha, Maharashtra - 442 001, India. E-mail: rohit_gn@ 123456yahoo.com
                Article
                AYU-35-63
                10.4103/0974-8520.141940
                4213972
                07844a0d-3761-42e7-a08c-f9db076f0a5a
                Copyright: © AYU (An International Quarterly Journal of Research in Ayurveda)

                This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                Categories
                Pharmaceutical Standardization

                Complementary & Alternative medicine
                kupipakwa rasayana,rajata sindura,x-ray diffraction
                Complementary & Alternative medicine
                kupipakwa rasayana, rajata sindura, x-ray diffraction

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