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      Are Japanese and European gastric cancer the same biological entity? An immunohistochemical study.

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      British Journal of Cancer

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          Abstract

          To examine the suggested biological difference between Japanese and British gastric cancers, immunohistochemistry was used to demonstrate eight markers of biological activity in a matched series of 40 Japanese and 33 British cases. There were no differences in the proportions of Japanese and British tumours positive to epidermal growth factor, epidermal growth factor receptor, transforming growth factor alpha, cripto or p53. A significantly greater proportion of British tumours were positive to c-erbB-2 whilst a significantly greater proportion of Japanese tumours were positive to nm23. British tumours had a significantly greater mean proliferating cell nuclear antigen proliferation index than Japanese tumours. These differences could be clinically significant.

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          Author and article information

          Journal
          Br J Cancer
          British Journal of Cancer
          0007-0920
          1532-1827
          October 1995
          : 72
          : 4
          : 976-980
          Affiliations
          Department of Academic Surgery, Chelsea and Westminster Hospital, London.
          Article
          2034064
          7547252
          07c22e55-c3b5-4e4b-8e18-3ac810c4a4e1
          History
          Categories
          Research Article

          Oncology & Radiotherapy
          Oncology & Radiotherapy

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