The dopamine D 1, D 2, D 3 receptors, vesicular monoamine transporter type-2 (VMAT2), and dopamine transporter (DAT) densities were measured in 11 aged human brains (aged 77–107.8, mean: 91 years) by quantitative autoradiography. The density of D 1 receptors, VMAT2, and DAT was measured using [ 3H]SCH23390, [ 3H]dihydrotetrabenazine, and [ 3H]WIN35428, respectively. The density of D 2 and D 3 receptors was calculated using the D 3-preferring radioligand, [ 3H] WC-10 and the D 2-preferring radioligand [ 3H]raclopride using a mathematical model developed previously by our group. Dopamine D 1, D 2, and D 3 receptors are extensively distributed throughout striatum; the highest density of D 3 receptors occurred in the nucleus accumbens (NAc). The density of the DAT is 10–20-fold lower than that of VMAT2 in striatal regions. Dopamine D 3 receptor density exceeded D 2 receptor densities in extrastriatal regions, and thalamus contained a high level of D 3 receptors with negligible D 2 receptors. The density of dopamine D 1 linearly correlated with D 3 receptor density in the thalamus. The density of the DAT was negligible in the extrastriatal regions whereas the VMAT2 was expressed in moderate density. D 3 receptor and VMAT2 densities were in similar level between the aged human and aged rhesus brain samples, whereas aged human brain samples had lower range of densities of D 1 and D 2 receptors and DAT compared with the aged rhesus monkey brain. The differential density of D 3 and D 2 receptors in human brain will be useful in the interpretation of PET imaging studies in human subjects with existing radiotracers, and assist in the validation of newer PET radiotracers having a higher selectivity for dopamine D 2 or D 3 receptors.