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      Absence of natriuretic peptide clearance receptor attenuates TGF-β1-induced selective atrial fibrosis and atrial fibrillation

      1 , 1 , 1 , 1

      Cardiovascular Research

      Oxford University Press (OUP)

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          Abstract

          TGF-β1 plays an important role in atrial fibrosis and atrial fibrillation (AF); previous studies have shown that the atria are more susceptible to TGF-β1 mediated fibrosis than the ventricles. Natriuretic peptides (NPs) play an important role in cardiac remodelling and fibrosis, but the role of natriuretic peptide clearance (NPR-C) receptor is largely unknown. We investigated the role of NPR-C in modulating TGF-β1 signalling in the atria.

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          Author and article information

          Journal
          Cardiovascular Research
          Oxford University Press (OUP)
          0008-6363
          1755-3245
          February 01 2019
          February 01 2019
          September 18 2018
          February 01 2019
          February 01 2019
          September 18 2018
          : 115
          : 2
          : 357-372
          Affiliations
          [1 ]Division of Cardiology, Cardiovascular Research Institute, University of California, San Francisco, 505 Parnassus Avenue, M1182, Box 0124, San Francisco, CA, USA
          Article
          10.1093/cvr/cvy224
          30239604
          © 2018

          https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model

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