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TGF-β1 plays an important role in atrial fibrosis and atrial fibrillation (AF); previous
studies have shown that the atria are more susceptible to TGF-β1 mediated fibrosis
than the ventricles. Natriuretic peptides (NPs) play an important role in cardiac
remodelling and fibrosis, but the role of natriuretic peptide clearance (NPR-C) receptor
is largely unknown. We investigated the role of NPR-C in modulating TGF-β1 signalling
in the atria.