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      Has the Microbiota Played a Critical Role in the Evolution of the Adaptive Immune System?

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      Science
      American Association for the Advancement of Science (AAAS)

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          Abstract

          Although microbes have been classically viewed as pathogens, it is now well established that the majority of host-bacterial interactions are symbiotic. During development and into adulthood, gut bacteria shape the tissues, cells, and molecular profile of our gastrointestinal immune system. This partnership, forged over many millennia of coevolution, is based on a molecular exchange involving bacterial signals that are recognized by host receptors to mediate beneficial outcomes for both microbes and humans. We explore how specific aspects of the adaptive immune system are influenced by intestinal commensal bacteria. Understanding the molecular mechanisms that mediate symbiosis between commensal bacteria and humans may redefine how we view the evolution of adaptive immunity and consequently how we approach the treatment of numerous immunologic disorders.

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          Author and article information

          Journal
          Science
          Science
          American Association for the Advancement of Science (AAAS)
          0036-8075
          1095-9203
          December 23 2010
          December 24 2010
          December 23 2010
          December 24 2010
          : 330
          : 6012
          : 1768-1773
          Article
          10.1126/science.1195568
          3159383
          21205662
          07d259e4-7a35-43c3-85cd-9ba39d85c6bd
          © 2010
          History

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